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Literature summary for 3.4.24.71 extracted from

  • Korth, P.; Egidy, G.; Parnot, C.; LeMoullec, J.M.; Corvol, P.; Pinet, F.
    Construction, expression and characterization of a soluble form of human endothelin-converting-enzyme-1 (1997), FEBS Lett., 417, 365-370.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
chymostatin
-
Homo sapiens
E-64
-
Homo sapiens
pepstatin A
-
Homo sapiens
PMSF
-
Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
sECE, constructed by fusing the cleavable signal peptide of pro-opiomelanocortin in frame to complete extracellular domain of ECE-1, expressed in CHO cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
Homo sapiens
EDTA
-
Homo sapiens
additional information not inhibited by thiorphan and captopril Homo sapiens
phosphoramidon
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane integral membrane protein Homo sapiens 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
115000
-
2 * 110000-140000, gel filtration, 2 * 115000, isoenzyme sECE, gel filtration Homo sapiens
250000 300000 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
big endothelin-I + H2O Homo sapiens key enzyme in the biosynthesis of the endothelins endothelin + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
human
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
big endothelin-I + H2O
-
Homo sapiens endothelin + ?
-
?
big endothelin-I + H2O key enzyme in the biosynthesis of the endothelins Homo sapiens endothelin + ?
-
?

Subunits

Subunits Comment Organism
dimer 2 * 110000-140000, gel filtration, 2 * 115000, isoenzyme sECE, gel filtration Homo sapiens

Synonyms

Synonyms Comment Organism
ECE-1
-
Homo sapiens
endothelin-converting-enzyme-1
-
Homo sapiens
sECE
-
Homo sapiens