Activating Compound | Comment | Organism | Structure |
---|---|---|---|
chymostatin | - |
Homo sapiens | |
E-64 | - |
Homo sapiens | |
pepstatin A | - |
Homo sapiens | |
PMSF | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
sECE, constructed by fusing the cleavable signal peptide of pro-opiomelanocortin in frame to complete extracellular domain of ECE-1, expressed in CHO cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | - |
Homo sapiens | |
EDTA | - |
Homo sapiens | |
additional information | not inhibited by thiorphan and captopril | Homo sapiens | |
phosphoramidon | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | integral membrane protein | Homo sapiens | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
115000 | - |
2 * 110000-140000, gel filtration, 2 * 115000, isoenzyme sECE, gel filtration | Homo sapiens |
250000 | 300000 | gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
big endothelin-I + H2O | Homo sapiens | key enzyme in the biosynthesis of the endothelins | endothelin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
big endothelin-I + H2O | - |
Homo sapiens | endothelin + ? | - |
? | |
big endothelin-I + H2O | key enzyme in the biosynthesis of the endothelins | Homo sapiens | endothelin + ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 110000-140000, gel filtration, 2 * 115000, isoenzyme sECE, gel filtration | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ECE-1 | - |
Homo sapiens |
endothelin-converting-enzyme-1 | - |
Homo sapiens |
sECE | - |
Homo sapiens |