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Literature summary for 3.4.24.71 extracted from

  • Roosterman, D.; Kempkes, C.; Cottrell, G.S.; Padilla, B.E.; Bunnett, N.W.; Turck, C.W.; Steinhoff, M.
    Endothelin-converting enzyme-1 degrades internalized somatostatin-14 (2008), Endocrinology, 149, 2200-2207.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.71

Inhibitors

Inhibitors Comment Organism Structure
additional information prevention of acidification of endosomes using bafilomycin A1 inhibits the degradation of internalized somatostatin-14 Homo sapiens
SM-19712 a specific ECE-1 inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome early endosomes from sequestration of recombinant somatostatin receptor subtype 2A, sst2A, in HEK-293 cells after induction by somatostatin-14 or octreotide, co-localization od ECE-1 and sst2A, overview Homo sapiens 5768
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information activity with octreotide Homo sapiens ?
-
 ?
Somatostatin-14 + H2O i.e. SST-14, degradation of rat substrate internalized via recombinantly expressed somatostatin receptor subtype sst2A into HEK-293 cells Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ECE-1
-
 Homo sapiens
endothelin-converting enzyme-1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens