3.4.24.71: endothelin-converting enzyme 1
This is an abbreviated version!
For detailed information about endothelin-converting enzyme 1, go to the full flat file.
Word Map on EC 3.4.24.71
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3.4.24.71
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endothelins
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phosphoramidon
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artery
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vasoconstrictor
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endopeptidase
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cardiovascular
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hypertension
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cardiac
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pulmonary
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angiotensin
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neprilysin
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tone
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vasoactive
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metalloprotease
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vessel
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coronary
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phosphoramidon-sensitive
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metallopeptidases
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contractile
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preproet-1
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vasospasm
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thiorphan
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atrial
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natriuretic
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pressor
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ventricular
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aortic
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angiotensin-converting
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preproendothelin-1
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endothelium-derived
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et-1-induced
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insulin-degrading
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drug development
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baecs
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hemodynamic
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medicine
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vasopeptidase
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etb-receptors
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3.4.24.11
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metalloendopeptidase
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subarachnoid
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chymase
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conscious
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ednra
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sarafotoxin
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basilar
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ppet-1
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21-amino
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prepro
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enzyme-2
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bosentan
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et-1-mediated
- 3.4.24.71
- endothelins
- phosphoramidon
- artery
-
vasoconstrictor
- endopeptidase
- cardiovascular
- hypertension
- cardiac
- pulmonary
- angiotensin
- neprilysin
-
tone
-
vasoactive
- metalloprotease
- vessel
- coronary
-
phosphoramidon-sensitive
- metallopeptidases
-
contractile
-
preproet-1
- vasospasm
- thiorphan
-
atrial
-
natriuretic
-
pressor
- ventricular
- aortic
-
angiotensin-converting
- preproendothelin-1
-
endothelium-derived
-
et-1-induced
-
insulin-degrading
- drug development
-
baecs
-
hemodynamic
- medicine
-
vasopeptidase
-
etb-receptors
-
3.4.24.11
- metalloendopeptidase
-
subarachnoid
- chymase
-
conscious
-
ednra
- sarafotoxin
-
basilar
-
ppet-1
-
21-amino
-
prepro
- enzyme-2
- bosentan
-
et-1-mediated
Reaction
Hydrolysis of the -Trp21-/-Val- bond in big endothelin to form endothelin 1 =
Synonyms
ECE, ECE-1, ECE-1b, ECE-3, ECE1, endothelin converting enzyme, endothelin converting enzyme-1, Endothelin-converting enzyme, endothelin-converting enzyme 1, endothelin-converting enzyme 1 (ECE-1), endothelin-converting enzyme I, endothelin-converting enzyme-1, endothelin-converting-enzyme-1, ET converting enzyme, hECE-1, More, sECE, solECE-1
ECTree
3.4.24.71 endothelin-converting enzyme 1Advanced search results
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results (Source Tissue
Source Tissue on EC 3.4.24.71 - endothelin-converting enzyme 1
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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ECE-1 overexpression, immunohistochemic ECE-1 expression analysis of 600 different samples, the expression of ECE-1 is correlated to VEGF expression, overview
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ECE-1 expression in Alzheimer's disease brain shows no significant difference compared with age-matched controls
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from healthy persons and from patients with Crohn's disease, enzyme expression anaylsis in different samples, healthy tissue shows enzyme expression mainly in the muscular layer and the vasculature, while in Crohn'sdisease colonic tissue, the enzyme is found at inflammatory sites and fibrotic tissue, overview
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enzyme distribution in the endometrium during different developmental phases, the enzyme expression varies during the menstrual cycle, epithelial cell, overview
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enzyme expression in chalizia in meibomian adenomers, conjunctival epithelium, tarsal mucous glands, and in inflammatory cells, immunohistochemic analysis, overview
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from blood, determination of enzyme expression by immunohistochemical analysis using a combination of ECE-1 isoform-specific antibodies, expression of isozymes ECE-1a and ECE-1c
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increased ECE-1 content in hypercholesterolemic patients
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primary cells derived from malignant tissue from radical prostatectomies, expression and localization of the ECE-1 isozymes, overview, upregulation of the isozyme ECE-1c
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primary cells derived from benign tissue from radical prostatectomies, expression and localization of the ECE-1 isozymes, overview
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dorsal skin, ECE-1 promotes re-sensitization of SP-induced inflammation
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aortic, determination of enzyme expression by immunohistochemical analysis using a combination of ECE-1 isoform-specific antibodies, expression of isozyme ECE-1a
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ECE-1 protein level in stellate cell from bile duct ligation-injured liver is increased twofold compared to those in normal stellate cell, ECE-1 protein is also up-regulated in cell from CCl4-injured liver and culture-activated stellate cell. Exposure of stellate cell from injured livers to TGF-betaincreases ECE-1 expression
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ECE-1 promotes re-sensitization of SP-induced inflammation
additional information
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determination of enzyme expression by immunohistochemical analysis on atherosclerotic and nonatherosclerotic vascular tissue using a combination of ECE-1 isoform-specific antibodies, distinct expression patterns for ECE-1a and ECE-1c, overview
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increased ECE-1 protein content (immunohistochemistry, immunoblot) and mRNA expression (Northern blot) in apolipoprotein E-deficient mouse
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increased ECE-1 protein content (immunohistochemistry, immunoblot) and mRNA expression (Northern blot) in apolipoprotein E-deficient mouse
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treatment with oxidized-low density lipoproteins results in increased ECE-1 protein content, mRNA expression and promotor activity
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analysis of the levels of ECE-1 expression and distribution under normal and pathologic conditions of Alzheimer disease, overview
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expression analysis of ECE-1 in the temporal cortex of patients with Alzheimer's disease, vascular dementia, and controls, overview. ECE-1 occurs in vascular endothelial cells. ECE-1 mRNA or protein levels, of either full-length ECE-1 or soluble spliced variant, ECE-1sv, in Alzheimer's disease or vascular dementia show no differences compared to controls
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analysis of the levels of ECE-1 expression and distribution under normal and pathologic conditions of Alzheimer disease, overview
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quantitative immunohistochemic analysis of enzyme distribution in autopsy specimen of post-percutaneous coronary intervention, PCI, sites and restenotic sites, the enzyme is detectable in the first 3 months after PCI, overview
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no increased ECE-1 protein content (immunohistochemistry, immunoblot) and mRNA expression (Northern blot) in apolipoprotein E-deficient mouse
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no increased ECE-1 protein content (immunohistochemistry, immunoblot) and mRNA expression (Northern blot) in apolipoprotein E-deficient mouse
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increased ECE-1 protein content (immunohistochemistry, immunoblot) and mRNA expression (Northern blot) in apolipoprotein E-deficient mouse
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increased ECE-1 protein content (immunohistochemistry, immunoblot) and mRNA expression (Northern blot) in apolipoprotein E-deficient mouse
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medulla and cortex, expression analysis after enzyme induction, overview
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increased ECE-1 protein content (immunohistochemistry, immunoblot) and mRNA expression (Northern blot) in apolipoprotein E-deficient mouse
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increased ECE-1 protein content (immunohistochemistry, immunoblot) and mRNA expression (Northern blot) in apolipoprotein E-deficient mouse
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ECE-1 occurs in neurons in the cerebral cortex, hippocampus, amygdala, basal forebrain nuclei, diencephalon, brain stem and cerebellar hemisphere
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elevated ECE-1 expression level when developing lipopolysaccharide-induced premature delivery (Western blot)
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elevated ECE-1 expression level when developing lipopolysaccharide-induced premature delivery (Western blot)
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ECE-1 is secreted to the medium, ECE-1 shedding from the surface of endothelial cells
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elevated ECE-1 expression level when developing lipopolysaccharide-induced premature delivery (Western blot)
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elevated ECE-1 expression level when developing lipopolysaccharide-induced premature delivery (Western blot)
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additional information
ECE1 is ubiquitously expressed in killifish
additional information
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expression of ECE-1 is significantly reduced in the cortex of adult rats after 15 mins of global ischemia, and is also significantly reduced in the striatum of rats subjected to prenatal hypoxia
