Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a target for drug design in cardiovascular disease | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | dual neprilysin/ECE knock-out mice show additive effects on amyloid-beta peptide accumulation, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CGS 26303 | - |
Mus musculus | |
CGS 26393 | slight inhibition | Mus musculus | |
CGS 35066 | - |
Mus musculus | |
CGS 35339 | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid-beta peptide + H2O | Mus musculus | degradation | ? | - |
? | |
additional information | Mus musculus | endothelin-converting enzyme function as vasopeptidase | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid-beta peptide + H2O | degradation | Mus musculus | ? | - |
? | |
additional information | endothelin-converting enzyme function as vasopeptidase | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ECE | - |
Mus musculus |