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Literature summary for 3.4.24.71 extracted from

  • Eckman, E.A.; Adams, S.K.; Troendle, F.J.; Stodola, B.A.; Kahn, M.A.; Fauq, A.H.; Xiao, H.D.; Bernstein, K.E.; Eckman, C.B.
    Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme (2006), J. Biol. Chem., 281, 30471-30478.
    View publication on PubMed

Application

Application Comment Organism
drug development the enzyme is a target for drug design in cardiovascular disease Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information dual neprilysin/ECE knock-out mice show additive effects on amyloid-beta peptide accumulation, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
CGS 26303
-
Mus musculus
CGS 26393 slight inhibition Mus musculus
CGS 35066
-
Mus musculus
CGS 35339
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid-beta peptide + H2O Mus musculus degradation ?
-
?
additional information Mus musculus endothelin-converting enzyme function as vasopeptidase ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid-beta peptide + H2O degradation Mus musculus ?
-
?
additional information endothelin-converting enzyme function as vasopeptidase Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
ECE
-
Mus musculus