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Literature summary for 3.4.24.71 extracted from

  • Smollich, M.; Goette, M.; Yip, G.W.; Yong, E.S.; Kersting, C.; Fischgraebe, J.; Radke, I.; Kiesel, L.; Wuelfing, P.
    On the role of endothelin-converting enzyme-1 (ECE-1) and neprilysin in human breast cancer (2007), Breast Cancer Res. Treat., 106, 361-369.
    View publication on PubMed
Search for more literature for 3.4.24.71

Inhibitors

Inhibitors Comment Organism Structure
RO 67-7447 i.e. (2S,4R)-4-mercapto-2-(2,4,5-trifluoro-benzyloxymethyl)-pyrrolidine-1-carboxylic acid 2-methoxycarbonyl-phenyl ester, a selective ECE-1 inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane ECE-1 is a type II membrane protease Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ ECE-1 belongs to the neprilysin family of zinc metallopeptidases Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
big endothelin-1 + H2O Homo sapiens ECE-1 inhibition in MCF-7 breast cancer cells leads to a significantly decreased ET-1 expression and reduced cell invasiveness, overview endothelin-1 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast carcinoma cell ECE-1 overexpression, immunohistochemic ECE-1 expression analysis of 600 different samples, the expression of ECE-1 is correlated to VEGF expression, overview Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
big endothelin-1 + H2O activation Homo sapiens endothelin-1 + ?
-
 ?
big endothelin-1 + H2O ECE-1 inhibition in MCF-7 breast cancer cells leads to a significantly decreased ET-1 expression and reduced cell invasiveness, overview Homo sapiens endothelin-1 + ?
-
 ?

Synonyms

Synonyms Comment Organism
ECE-1
-
 Homo sapiens
endothelin-converting enzyme-1
-
 Homo sapiens
More ECE-1 is a type II membrane protease belonging to the neprilysin family of zinc metallopeptidases Homo sapiens