Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ECEi | addition of an ECE-1 specific inhibitor (ECEi) to PC-3 cells reduces phosphorylation of focal adhesion kinase | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
PC-3 cell | - |
Homo sapiens | - |
PNT-1A cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
ECE-1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | siRNA-mediated knockdown of ECE-1 results in a significant reduction in FAK phosphorylation | down |
Homo sapiens | transient ECE-1 overexpression in PNT1-a cells increases FAK phosphorylation | up |
General Information | Comment | Organism |
---|---|---|
malfunction | siRNA-mediated knockdown of ECE-1 results in a significant reduction in FAK phosphorylation. Transient ECE-1 overexpression in PNT1-a cells increases FAK phosphorylation | Homo sapiens |
physiological function | ECE-1 influences PC cell invasion via both ET-1-mediated FAK phosphorylation and ET-1 independent mechanisms | Homo sapiens |