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Literature summary for 3.4.24.71 extracted from
- Substance P stimulates endothelin 1 secretion via endothelin-converting enzyme 1 and promotes melanogenesis in human melanocytes (2015), J. Invest. Dermatol., 135, 551-559.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CGS-35066 | - |
Homo sapiens |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 80000 | - |
x * 80000, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| big endothelin + H2O | Homo sapiens | - |
endothelin + ? | - |
? | |
| Substance P + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P42892 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| melanocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| big endothelin + H2O | - |
Homo sapiens | endothelin + ? | - |
? | |
| Substance P + H2O | - |
Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 80000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ECE1 | - |
Homo sapiens |
| endothelin-converting enzyme 1 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme is involved in substance P-induced pigmentation. The enzyme is essential for endothelin 1 secretion in melanocytes | Homo sapiens |
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Release 2023.1 (January 2023)
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