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3.4.24.71: endothelin-converting enzyme 1

This is an abbreviated version!
For detailed information about endothelin-converting enzyme 1, go to the full flat file.

Word Map on EC 3.4.24.71

Reaction

Hydrolysis of the -Trp21-/-Val- bond in big endothelin to form endothelin 1 =

Synonyms

ECE, ECE-1, ECE-1b, ECE-3, ECE1, endothelin converting enzyme, endothelin converting enzyme-1, Endothelin-converting enzyme, endothelin-converting enzyme 1, endothelin-converting enzyme 1 (ECE-1), endothelin-converting enzyme I, endothelin-converting enzyme-1, endothelin-converting-enzyme-1, ET converting enzyme, hECE-1, More, sECE, solECE-1

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.71 endothelin-converting enzyme 1

Cloned

Cloned on EC 3.4.24.71 - endothelin-converting enzyme 1

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
bovine
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COS-1 cell membrane with overexpression of human ECE-1
DNA and amino acid sequence determination and anaylsis, genotyping, the ECE encoding gene shows several single nucleotide polymorphisms, overview
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DNA and amino acid sequence determination and anaylsis, phylogenetic analysis
ECE-1 is endogenously expressed in HMEC-1 cells (RT-PCR, immunofluorescence)
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ECE-1 mRNA level is 42% lower in stenotic valves
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expressed in Chinese hamster ovary cells
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expressed in Chinese hamster ovary CHO-K1 cells
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expressed in COS-cells
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expressed in NCM-460 cells
expression of ECE-1 is significantly higher in the solid tumors compared with effusions
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extracellular domain of monomeric human ECE-1 (C428S) mutant (Q90-W770) is amplified by PCR and produced recombinantly in Escherichia coli (inclusion bodies)
gene ECE-1b , the ECE-1 gene is located on chromosome 1, 1p36, genotyping
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generation of apolipoprotein E-deficient mouse from strain C57BL/6J
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GFP-tagged ECE-1 overexpression in HEK-293 cells
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isozyme genetic structure, overview, expression of wild-type isozyme ECE-1d and of truncated variant ECE-1sv lacking the signal peptide, expression analysis of isozymes and splicing variants, overview
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overexpression of GFP-tagged isozymes in HEK cell endosomes, subcellular localization, overview
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sECE, constructed by fusing the cleavable signal peptide of pro-opiomelanocortin in frame to complete extracellular domain of ECE-1, expressed in CHO cells
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solECE-1 constructed by fusing the cleavable N-terminalsignal sequence of human alkaline phosphatase in frame with the entire extracellular domain of ECE-1, transfected into CHO-K1 cells
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