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Literature summary for 3.4.24.71 extracted from

  • Jensen, D.; Halls, M.; Murphy, J.; Canals, M.; Cattaruzza, F.; Poole, D.; Lieu, T.; Koon, H.; Pothoulakis, C.; Bunnett, N.
    Endothelin-converting enzyme 1 and beta-arrestins exert spatiotemporal control of substance P-induced inflammatory signals (2014), J. Biol. Chem., 289, 20283-20294.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in NCM-460 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
SM-19712
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome
-
 Homo sapiens 5768
-
membrane transmembrane protein Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Substance P + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P42892
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colonocyte
-
 Homo sapiens
-
HEK-293 cell
-
 Homo sapiens
-
NCM-460 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Substance P + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ECE-1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the primary function of ECE-1 in substance P-dependent inflammatory signaling is to promote resensitization, which allows the sustained neurokinin 1 receptor signaling from the plasma membrane that drives inflammation Homo sapiens