3.4.24.71: endothelin-converting enzyme 1
This is an abbreviated version!
For detailed information about endothelin-converting enzyme 1, go to the full flat file.
Word Map on EC 3.4.24.71
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3.4.24.71
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endothelins
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phosphoramidon
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artery
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vasoconstrictor
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endopeptidase
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cardiovascular
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hypertension
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cardiac
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pulmonary
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angiotensin
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neprilysin
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tone
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vasoactive
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metalloprotease
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vessel
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coronary
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phosphoramidon-sensitive
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metallopeptidases
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contractile
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preproet-1
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vasospasm
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thiorphan
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atrial
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natriuretic
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pressor
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ventricular
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aortic
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angiotensin-converting
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preproendothelin-1
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endothelium-derived
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et-1-induced
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insulin-degrading
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drug development
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baecs
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hemodynamic
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medicine
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vasopeptidase
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etb-receptors
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3.4.24.11
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metalloendopeptidase
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subarachnoid
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chymase
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conscious
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ednra
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sarafotoxin
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basilar
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ppet-1
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21-amino
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prepro
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enzyme-2
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bosentan
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et-1-mediated
- 3.4.24.71
- endothelins
- phosphoramidon
- artery
-
vasoconstrictor
- endopeptidase
- cardiovascular
- hypertension
- cardiac
- pulmonary
- angiotensin
- neprilysin
-
tone
-
vasoactive
- metalloprotease
- vessel
- coronary
-
phosphoramidon-sensitive
- metallopeptidases
-
contractile
-
preproet-1
- vasospasm
- thiorphan
-
atrial
-
natriuretic
-
pressor
- ventricular
- aortic
-
angiotensin-converting
- preproendothelin-1
-
endothelium-derived
-
et-1-induced
-
insulin-degrading
- drug development
-
baecs
-
hemodynamic
- medicine
-
vasopeptidase
-
etb-receptors
-
3.4.24.11
- metalloendopeptidase
-
subarachnoid
- chymase
-
conscious
-
ednra
- sarafotoxin
-
basilar
-
ppet-1
-
21-amino
-
prepro
- enzyme-2
- bosentan
-
et-1-mediated
Reaction
Hydrolysis of the -Trp21-/-Val- bond in big endothelin to form endothelin 1 =
Synonyms
ECE, ECE-1, ECE-1b, ECE-3, ECE1, endothelin converting enzyme, endothelin converting enzyme-1, Endothelin-converting enzyme, endothelin-converting enzyme 1, endothelin-converting enzyme 1 (ECE-1), endothelin-converting enzyme I, endothelin-converting enzyme-1, endothelin-converting-enzyme-1, ET converting enzyme, hECE-1, More, sECE, solECE-1
ECTree
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Engineering
Engineering on EC 3.4.24.71 - endothelin-converting enzyme 1
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C338A
the mutation in isoform ECE-1b creates a new E2F-2 transcription factor binding site and enhances expression of this intracellular isoform
additional information
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ECE-1 inhibition or knockdown traps CLR/RAMP1 and beta-arrestin2 in endosomes and inhibits CLR/RAMP1 recycling and resensitization, whereas ECE-1 overexpression has the opposite effect, overview
additional information
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increased ECE activity in PKCepsilon-transfected EA.hy926 cells
additional information
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the ECE encoding gene shows polymorphisms, genotyping, overview
additional information
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overexpression of ECE-1a or 1b in CHO cells results in a 75-90% reduction in Abeta1-40 and a 45-60% reduction in Abeta1-42, completely abolished by treatment with phosphoramidon
additional information
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the C338A polymorphism, that is located in the ECE-1 gene promoter, occurs in gene ECE-1b in carotid atherosclerosis, genotyping of a Chinese population, carotid atherosclerosis patients and healthy subjects, overview
additional information
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construction of transgenic mice overexpressing human amyloid-beta peptide and protein kinase C epsilon, overview, increased ECE activity in PKCepsilon-transfected EA.hy926 cells
additional information
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dual neprilysin/ECE knock-out mice show additive effects on amyloid-beta peptide accumulation, overview