Literature summary for 3.4.24.71 extracted from

Wallace, E.M.; Moliterni, J.A.; Moskal, M.A.; Neubert, A.D.; Marcopulos, N.; Stamford, L.B.; Trapani, A.J.; Savage, P.; Chou, M.; Jeng, A.Y.
Design and synthesis of potent, selective inhibitors of endothelin-converting enzyme (1998), J. Med. Chem., 41, 1513-1523.

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Application

Application	Comment	Organism
medicine	elevated plasma levels of endothelin-1 found in several diseases like asthma, hypertension, cerebral vacospasm, congestive heart failure and chronic and acute renal failure, blockade of the ET-1 system could have therapeutic utility	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism
(R,R)-5-[(2,4-difluorophenyl)-2-(3,3,3-trifluoro-2-methoxy-2-phenylpropionyl)amino]pent-4-ynoic acid methyl ester	-	Homo sapiens
(R,S)-5-[(2,4-difluorophenyl)-2-(3,3,3-trifluoro-2-methoxy-2-phenylpropionyl)amino]pent-4-ynoic acid methyl ester	-	Homo sapiens
(S)-2-amino-5-(2,4-difluorophenyl)pent-4-ynoic acid methyl ester	-	Homo sapiens
(S)-2-[(tert-butoxycarbonyl)amino]-5-(2,4-difluorophenyl)pent-4-ynoic acid	-	Homo sapiens
(S)-2-[(tert-butoxycarbonyl)amino]-5-(2,4-difluorophenyl)pent-4-ynoic acid methyl ester	-	Homo sapiens
(S)-2-[(tert-butoxycarbonyl)amino]pent-4-ynoic acid	-	Homo sapiens
(S)-3-[5-[1-amino-4-(2-methoxyphenyl)but-3-ynyl]tetrazol-1-yl]propionitrile	-	Homo sapiens
(S)-5-(2,4-difluorophenyl)-2-[[(dimethoxyphosphoryl)methyl]amino]pent-4-ynoic acid	-	Homo sapiens
(S)-5-(2,4-difluorophenyl)-2-[[(dimethoxyphosphoryl)methyl]amino]pent-4-ynoic acid methyl ester	-	Homo sapiens
(S)-[1-[(2-cyanoethyl)-1-H-tetrazol-5-yl]-4-(2-methoxyphenyl)but-3-ynyl]carbamic acid tert-butyl ester	-	Homo sapiens
(S)-[1-[(2-cyanoethyl)carbamoyl]-4-(2-methoxyphenyl)but-3-ynyl]carbamic acid tert-butyl ester	-	Homo sapiens
(S)-[1-[(2-cyanoethyl)carbamoyl]but-3-ynyl]carbamic acid tert-butyl ester	-	Homo sapiens
(S)-[[1-[[(2-biphenyl-4-ylethyl)-carbamoyl]-4-(2-fluorophenyl)but-3-ynyl]amino]methyl]phosphonic acid	-	Homo sapiens
(S)-[[[1-[1-(2-cyanoethyl)-1-H-tetrazol-5-yl]-4-(2-methoxyphenyl)but-3-ynyl]amino]methyl] phosphonic acid diphenyl ester	-	Homo sapiens
(S)-[[[[4-(2-methoxyphenyl)-1-H-tetrazol-5-yl]but-3-ynyl]amino]methyl] phosphonic acid	-	Homo sapiens
(S)-[[[[4-(2-methoxyphenyl)-1-H-tetrazol-5-yl]but-3-ynyl]amino]methyl] phosphonic acid diphenyl ester	-	Homo sapiens
(S,S)-2-[5-(2,4-difluorophenyl)-2-[[(dimethoxyphosphoryl)methyl]amino]pent-4-ynoyl]-4-methylpentanoic acid methyl ester	-	Homo sapiens
(S,S)-2-[[2-amino-5-(2-chlorophenyl)pent-4-ynoyl]amino]-4-methylpentanoic acid methyl ester	-	Homo sapiens
(S,S)-2-[[2-[(tert-butoxycarbonyl)amino]-5-(2-chlorophenyl)pent-4-ynoyl]-amino]-4-methylpentanoic acid methyl ester	-	Homo sapiens
(S,S)-2-[[2-[(tert-butoxycarbonyl)amino]pent-4-ynoyl]-amino]-4-methylpentanoic acid methyl ester	-	Homo sapiens
(S,S)-2-[[5-(2,4-difluorophenyl)-2-[(phosphonomethyl)amino]pent-4-ynoyl]amino]-4-methylpentanoic acid	-	Homo sapiens
(S,S)-2-[[5-(2-chlorophenyl)-2-[(phosphonomethyl)amino]pent-4-ynoyl]amino]-4-methylpentanoic acid	-	Homo sapiens
(S,S)-2-[[5-(2-chlorophenyl)-2-[[(dimethoxyphosphoryl)-methyl]amino]pent-4-ynoyl]amino]-4-methylpentanoic acid methyl ester	-	Homo sapiens
(S,S)-2-[[5-(2-fluorophenyl)-2-[(phosphonomethyl)-amino]pent-4-ynoyl]amino]-4-methyl pentanoic acid	-	Homo sapiens
(S,S)-2-[[5-(3-fluorophenyl)-2-[(phosphonomethyl)-amino]pent-4-ynoyl]amino]-4-methyl pentanoic acid	-	Homo sapiens
(S,S)-5-phenyl-2-[(3,3,3-trifluoro-2-methoxy-2-phenylpropionyl)amino]pent-4-ynoic acid (2-cyanoethyl)amide	-	Homo sapiens
2-[(tert-butoxycarbonyl)amino]-5-(2,4-difluorophenyl)pent-4-ynoic acid methyl ester	-	Homo sapiens
cyclohexyl-2-[[5-(2,4-difluorophenyl)-2-[(phosphonomethyl)-amino]pent-4-ynoyl]amino]propionic acid	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
big endothelin-1 + H2O	Homo sapiens	final step of posttranslational processing of this peptide	endothelin-1 + ?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	human	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
big endothelin-1 + H2O	-	Homo sapiens	endothelin-1 + ?	-	?
big endothelin-1 + H2O	final step of posttranslational processing of this peptide	Homo sapiens	endothelin-1 + ?	-	?

Synonyms

Synonyms	Comment	Organism
ECE-1	-	Homo sapiens
Endothelin-converting enzyme	-	Homo sapiens