3.4.21.73: u-Plasminogen activator
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For detailed information about u-Plasminogen activator, go to the full flat file.
Word Map on EC 3.4.21.73
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3.4.21.73
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fibrinolytic
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pai-1
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artery
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metastasis
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thrombolysis
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tissue-type
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fibrin
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endothelial
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clot
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vein
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inhibitor-1
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infarct
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heparin
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streptokinase
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thrombus
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catheter
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venous
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myocardial
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fibrinogen
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embolism
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coronary
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bleeding
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angiogenesis
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hemorrhage
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coagulation
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anticoagulation
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single-chain
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zymography
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mmp-9
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metalloproteinases
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angioplasty
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patency
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angiography
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recanalization
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percutaneous
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thrombotic
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thromboembolism
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vitronectin
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occlusions
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kringle
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intraarterial
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pericellular
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transluminal
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intracoronary
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thrombectomy
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amidolytic
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2-antiplasmin
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euglobulin
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alteplase
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reocclusion
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drug development
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pharmacology
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analysis
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agriculture
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diagnostics
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medicine
- 3.4.21.73
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fibrinolytic
- pai-1
- artery
- metastasis
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thrombolysis
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tissue-type
- fibrin
- endothelial
- clot
- vein
- inhibitor-1
- infarct
- heparin
- streptokinase
- thrombus
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catheter
- venous
- myocardial
- fibrinogen
- embolism
- coronary
- bleeding
- angiogenesis
- hemorrhage
- coagulation
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anticoagulation
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single-chain
-
zymography
- mmp-9
- metalloproteinases
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angioplasty
-
patency
-
angiography
-
recanalization
-
percutaneous
-
thrombotic
- thromboembolism
- vitronectin
- occlusions
-
kringle
-
intraarterial
-
pericellular
-
transluminal
-
intracoronary
-
thrombectomy
-
amidolytic
-
2-antiplasmin
-
euglobulin
- alteplase
-
reocclusion
- drug development
- pharmacology
- analysis
- agriculture
- diagnostics
- medicine
Reaction
Specific cleavage of Arg-/-Val bond in plasminogen to form plasmin =
Synonyms
Abbokinase, Cellular plasminogen activator, Double-chain urokinase-type plasminogen activator, EC 3.4.21.31, EC 3.4.99.26, Plasminogen activator, urokinase-type, PLAU, Two-chain urokinase-type plasminogen activator, u-PA, U-plasminogen activator, UK, uPA, uPA-type Plg activator, Urinary esterase A, Urinary plasminogen activator, Urokinase, Urokinase plasminogen activator, urokinase type plasminogen activator, urokinase-plasminogen activator, urokinase-type PA, urokinase-type plasmin activator, urokinase-type plasminogen, Urokinase-type plasminogen activator, urokinase-type Plg activator, urokine-type plasminogen activator
ECTree
3.4.21.73 u-Plasminogen activatorAdvanced search results
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results (Source Tissue
Source Tissue on EC 3.4.21.73 - u-Plasminogen activator
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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silencing of transmembrane protein Notch1 by siRNA results in significant reduction in the expression of uPA and matrix metalloproteinase-9 gene transcripts. Knock-down of Notch also reduces the mRNA expression and protein levels of uPA and matrix metalloproteinase-9
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uPA shows extensive colocalization with alpha-granule proteins in both cultured Quebec platelet disease megakaryocytes and platelets, and with plasminogen in Quebec platelet disease platelets
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standard model of the balloon catheter injury of the carotid. Periadventitial application of recombinant uPA significantly reduces lumen size and vessel area encompassed by the external lamina both 1 and 4 days after treatment.In fallatory cells accumulate in the arterial adventitia at both 1 and 4 days after uPA treatment. Four days after injury in uPA-treated arteries, 3 proinflammatory and 2 oxidation-related genes are differentially expressed
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uPA, seprase and pipeptidylaminopeptidase IV immunoreactivity is found in dysplastic and cancer cells as well as in stromal cells adjacent to dysplasia and cancer sites, but not in normal epithelium. There is a significant association between uPA expression and sex, tumor size and histological classification in carcinomas. Squamous cell carcinoma lines display higher levels of uPA, seprase and dipeptidylaminopeptidase IV than normal esophageal epithelial cell lines
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human recombinant uPA induces stem cell migration. Retrovirus-mediated overexpression of uPA and uPA receptor in neuroblastoma NB-1691 cells induced robust migration of stem cells toward NB-1691 cell-conditioned media, compared with media derived from wild-type NB-1691 cells. Depletion of uPA from PC-3 prostate cancer cell-conditioned medium blocks stem cell migration
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silencing of transmembrane protein Notch1 by siRNA results in significant reduction in the expression of uPA and matrix metalloproteinase-9 gene transcripts. Knock-down of Notch also reduces the mRNA expression and protein levels of uPA and matrix metalloproteinase-9
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human lung cancer cell line H1415, activation of uPA and uPA receptor in malignant solid tumors augments neural and mesenchymal stem cell tropism. Expression levels of uPA receptor on human solid tumor cell linescorrelates with levels of uPA and soluble uPA receptor in tumor cell-conditioned media
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subline of MDA-MB-231, stably transfected with the bacterial lacZ gene
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CD34+ progenitor cells express normal amounts of uPA, while their differentiation into megakaryocytes results in abnormally increased expression of the uPA gene but not the flanking genes for vinculin or calcium/calmodulin-dependent protein kinase IIgamma on chromosome 10. uPA shows extensive colocalization with alpha-granule proteins in both cultured Quebec platelet disease megakaryocytes and platelets, and with plasminogen in Quebec platelet disease platelets
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uPA localizes strongly to natural killer cells of the placental bed, especially at 8-10 weeks of gestation. uPA activity is similar in uterine natural killer cell culture supernatant compared with total unseparated decidual cells. uPA receptor in uterine natural killer cell lysates is significantly stronger than in total decidual cell lysates. Inhibitors PAI-1 and PAI-2 are not detected in uterine natural killer cell culture supernatants
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retrovirus-mediated overexpression of uPA and uPA receptor in neuroblastoma NB-1691 cells induced robust migration of stem cells toward NB-1691 cell-conditioned media, compared with media derived from wild-type NB-1691 cells
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activation of uPA and uPA receptor in malignant solid tumors augments neural and mesenchymal stem cell tropism. Expression levels of uPA receptor on human solid tumor cell lines correlates with levels of uPA and soluble uPA receptor in tumor cell-conditioned media
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activation of uPA and uPA receptor in malignant solid tumors augments neural and mesenchymal stem cell tropism. Expression levels of uPA receptor on human solid tumor cell lines correlates with levels of uPA and soluble uPA receptor in tumor cell-conditioned media
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study on cocaine-induced conditioned-place preference in rats with bilateral intra-accumbens injections of uPA-expressing lentiviral vectors. Overexpression of uPA in the nucleus accumbens significantly augments cocaine-induced place preference. Reinstatement with a low dose of cocaine produces significantly greater preference to the cocaine-associated context. Inhibition of tuPA expression using doxycycline abolishes the augmented acquisition produced by overexpression of uPA but not the expression of the cocaine-induced conditioned-place preference. Cocaine-induced cocaine-induced conditioned-place preference and reinstatement may be dependent on active extracellular uPA
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uPA localizes strongly to natural killer cells of the placental bed, especially at 8-10 weeks of gestation. uPA activity is similar in uterine natural killer cell culture supernatant compared with total unseparated decidual cells. uPA receptor in uterine natural killer cell lysates is significantly stronger than in total decidual cell lysates. Inhibitors PAI-1 and PAI-2 are not detected in uterine natural killer cell culture supernatants
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overexpression of uPA mRNA in various stages of surgically excised pterygia specimens and cultured pterygium fibroblasts, expression is increased significantly following the progression of the pterygium, quantitative real-time PCR analysis, overview
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activation of uPA and uPA receptor in malignant solid tumors augments neural and mesenchymal stem cell tropism. Expression levels of uPA receptor on human solid tumor cell lines correlates with levels of uPA and soluble uPA receptor in tumor cell-conditioned media
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in sputum derived from patients with house dust mite allergic asthma, the medium concentration of uPA is significantly greater than in healthy control patients. The sputum concentration of uPA correlates with sputum total cell count and with logarithmically transformed exhaled nitric oxide concentration, but not with FEV1 or bronchial reactivity to histamine. Tge effect of uPA seems to be independent of its fibrinolytic activity
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activation of uPA and uPA receptor in malignant solid tumors augments neural and mesenchymal stem cell tropism. Expression levels of uPA receptor on human solid tumor cell lines correlates with levels of uPA and soluble uPA receptor in tumor cell-conditioned media
additional information
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A-549 alveolar epithelial cell cultured on a fibrin matrix, stimulation by interleukin 1beta results in increased levels of enzyme in culture supernatant
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patients with common variable immunodeficiency show increased levels of plasma uPA
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brain tissue of thermally injured rats displays an increase in the brain water content and the presence of Evans blue, temporally associated with an increased expression of endogenous tPA and uPA. Peripheral thermal injury does induce an increase in the permeability of the blood brain barrier
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induction of lateral fluid percussion brain injury results in up-regulation of uPA and ERK mitogen-activated protein kinase. uPA contributes to the impairment of sodium nitroprusside and PGE2-mediated cerebrovasodilatation through activation of low-density lipoprotein receptor and ERK mitogen-activated protein kinase
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differences in uPA and uPAR expression and clinicopathologic features of patients with mismatch repair-proficient colorectal cancer, immunohistochemic tissue analysis, overview
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silencing of transmembrane protein Notch1 by siRNA results in significant reduction in the expression of uPA and matrix metalloproteinase-9 gene transcripts. Knock-down of Notch also reduces the mRNA expression and protein levels of uPA and matrix metalloproteinase-9
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established by a spontaneous transformation of endothelial cells of a human umbilical vein, with a novel substitution in the kringle structure
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A-549 alveolar epithelial cell cultured on a fibrin matrix, stimulation by interleukin 1beta results in increased levels of enzyme in culture supernatant
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gastric biopsy probes. uPA, uPA receptor and inhibitor PAI-1 are expressed in H+/K+ ATPase- and vesicular monoamine transporter 2-expressing cells. uPA is also expressed in pepsinogen- and uPA receptor-containing cells. In each case, expression is increased in response to Helicobacter pylori, and for uPA, but not the receptor or PAI-1, requires the virulence factor CagE. Helicobacter pylori also stimulates soluble and cell surface-bound uPA activity
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uPAR is overexpressed in outer root sheath and interfollicle epidermis, and expressed in the outermost epithelial cells of the hair follicle and the basal keratinocytes of epidermis, the expression decreases with the development of the hair follicle
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hearts with end-stage failure and fibrosis have macrophage accumulation and elevated plasminogen activator activity, mechanisms that link macrophage accumulation and plasminogen activator activity with cardiac fibrosis, overview
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treatment with H2O2 upregulates expression of uPA. Hepatocyte growth factor modulates Rac-1 regulated production of reactive oxygen species through activation of Akt and reactive oxygen species regulates uPA production via MAP kinase
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treatment with H2O2 upregulates expression of uPA. Hepatocyte growth factor modulates Rac-1 regulated production of reactive oxygen species through activation of Akt and reactive oxygen species regulates uPA production via MAP kinase
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basal keratinocytes of epidermis at the hair follicle. Expression of uPA and uPA receptor is selectively induced at the very tip of the leading edge of the keratinocytes
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in mice model for kidney ischemia reperfusion injury, deficiency for uPA receptor, but not uPA protects from ischemia reperfusion injury. In the allogenic kidney transplant model, uPA receptor but not uPA deficiency of the allograft causes superior recipient survival and strongly attenuates loss of renal function
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enzyme level is extremely elevated in the edematous fluid of acutely injured lungs and pleurae
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cerebral cortical, release of enzyme during the recovery phase from ischemic stroke in vivo or hypoxia in vitro
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cerebral cortical, release of enzyme during the recovery phase from ischemic stroke in vivo or hypoxia in vitro
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activation of uPA and uPA receptor in malignant solid tumors augments neural and mesenchymal stem cell tropism. Expression levels of uPA receptor on human solid tumor cell lines correlates with levels of uPA and soluble uPA receptor in tumor cell-conditioned media. Depletion of uPA from PC-3 prostate cancer cell-conditioned medium blocks stem cell migration
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in a severe combined immunodeficient-human mouse model, PC-3 cells are the major source of uPA in the experimental bone tumor. Injection of uPA-silenced PC-3 cells in bone xenografts results in significant reduction of bone tumor burdens and protection of trabecular bones from destruction. The suppressed tumor growth is associated with the level of uPA expression but not with its activity. An increase in the expression of PAI-1, the endogenous uPA inhibitor, is found during in vitro tumor-stromal interactions. Up-regulation of PAI-1 in bone stromal cells and preosteoclasts/osteoblasts is due to soluble factor(s) released by PC cells, and the enhanced PAI-1 expression in turn stimulated PC cell migration
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silencing of transmembrane protein Notch1 by siRNA results in significant reduction in the expression of uPA and matrix metalloproteinase-9 gene transcripts. Knock-down of Notch also reduces the mRNA expression and protein levels of uPA and matrix metalloproteinase-9
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expression levels of urokinase-type plasminogen activator system in radical prostatectomy specimens, overview
additional information
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uPA is expressed differentially in colon and rectal cancers, expression analysis, overview
additional information
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increased uPA expression in several epileptogenic pathologies, including hippocampal sclerosis, and in developmental glioneuronal lesions, such as focal cortical dysplasia, cortical tubers in patients with the tuberous sclerosis complex and in gangliogliomas, immunohistochemic analysis, overview
additional information
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no or poor expression of uPA in LS513 normal fibroblast
additional information
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quantitative and immunuhistochemic analysis of the urokinase plasminogen activator, its cognate receptor uPAR and the uPA inhibitors PAI-1 and PAI-2 in normal human testis and seminomas, overview
additional information
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strong expression of uPA in addition to a Gleason score, positive surgical margin, and lymph node metastasis
additional information
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uPA and uPA receptor are expressed during invasive migration of the hair follicle, not under normal circumstances. uPAR promotes the invasive migration of hair follicles synergizing in manner dependent and independent of uPA during human prenatal morphogenesis
additional information
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the uPA receptor, a GPI-linked cell surface protein, occurs in macrophages infiltrating the central nervous system, and in the cerebrospinal fluid during a number of CNS pathologies
additional information
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the uPA receptor, a GPI-linked cell surface protein, occurs in macrophages infiltrating the central nervous system, and in the cerebrospinal fluid during a number of CNS pathologies
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