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Literature summary for 3.4.21.73 extracted from

  • Zha, X.; Diaz, R.; Franco, J.J.; Sanchez, V.F.; Fasoli, E.; Barletta, G.; Carvajal, A.; Bansal, V.
    Inhibitors of urokinase type plasminogen activator and cytostatic activity from crude plants extracts (2013), Molecules, 18, 8945-8958.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
additional information extracts of tropical plants show enzyme inhibition activity, e.g. extracts from Croton lucidus, Erythroxylum aerolatum, Tabebuia heterophylla, Lantana camara, Cananga odorata, and Amyris elemifera. Extracts from leaves of Croton lucidus, a small shrub in the Euphorbiaceae family, typically growing in the limestone hills, coastal forests in the subtropical dry forest life zone in southwestern Puerto Rico, show presence of a strong enzyme inhibitory activity, comparison of extract from petroleum ether, chloroform, ethyl acetate and n-butanol, overview. The chloroform extract shows the highest inhibitory potency with 74% inhibition and an IC50 value of 0.00352 mg/ml. Analysis of the cytostatic activity of the extracts on PaCa-2 cells, highest cytotxic effct by choroform, lowest by n-butanol extract Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P00749
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Homo sapiens
-
urine
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
uPA
-
 Homo sapiens
urokinase type plasminogen activator
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme plays an important role in the processes of tumor cell metastasis, aortic aneurysm, and multiple sclerosis Homo sapiens