Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.73 extracted from

  • Paland, N.; Gamliel-Lazarovich, A.; Coleman, R.; Fuhrman, B.
    Urokinase-type plasminogen activator (uPA) stimulates triglyceride synthesis in Huh7 hepatoma cells via p38-dependent upregulation of DGAT2 (2014), Atherosclerosis, 237, 200-207.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens P00749
-
-
Mus musculus
-
-
-
Mus musculus C57BL/6
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatoma cell
-
Homo sapiens
-
Huh-7 cell
-
Homo sapiens
-
liver
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
uPA
-
Mus musculus
uPA
-
Homo sapiens
Urokinase-type plasminogen activator
-
Mus musculus
Urokinase-type plasminogen activator
-
Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme receptor defciient mice show no lipid droplets in their livers compared to wild-type C57BL/6 mice and the triglyceride levels are significantly lower, phenotype, overview Mus musculus
physiological function the urokinase-type plasminogen activator regulates gene expression in the liver involving peroxisome-proliferator-activated receptor gamma's transcriptional activity and stimulates triglyceride synthesis in Huh-7 hepatoma cells via p38-dependent upregulation of diglyceride acyltransferase 2. Also, the amount of free fatty acids is highly up regulated by the enzyme through activation of the transcription factor SREBP-1., overview Homo sapiens