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Literature summary for 3.4.21.73 extracted from

  • Uchino, R.; Madhyastha, R.; Madhyastha, H.; Dhungana, S.; Nakajima, Y.; Omura, S.; Maruyama, M.
    NFkappaB-dependent regulation of urokinase plasminogen activator by proanthocyanidin-rich grape seed extract: effect on invasion by prostate cancer cells (2010), Blood Coagul. Fibrinolysis, 21, 528-533.
    View publication on PubMed
Search for more literature for 3.4.21.73

Inhibitors

Inhibitors Comment Organism Structure
additional information efficacy of grape seed extract in negatively regulating uPA expression and cell migration using highly metastatic androgen-independent PC3 prostate cancer cells as a model. Grape seed extract inhibits and downregulates NFkB-dependent urokinase plasminogen activator promoter activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PC-3 cell
-
 Homo sapiens
-
prostate cancer cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
uPA
-
 Homo sapiens
Urokinase plasminogen activator
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens efficacy of grape seed extract in downregulating uPA expression and cell migration using highly metastatic androgen-independent PC-3 prostate cancer cells as a model. Grape seed extract inhibits DNA-binding activity of the transcription factor nuclear factor kappa B, which in turn decreases NFkB-dependent uPA transcription. Grape seed extract also inhibits NFkB-dependent urokinase plasminogen activator promoter activity down

General Information

General Information Comment Organism
metabolism NFkappaB-dependent regulation of urokinase plasminogen activator Homo sapiens
physiological function the urokinase plasminogen activator system is implicated in cell migration and cancer metastasis Homo sapiens