Literature summary for 3.4.21.73 extracted from

Lee, K.H.; Choi, E.Y.; Hyun, M.S.; Eun, J.R.; Jang, B.I.; Kim, T.N.; Lee, H.J.; Lee, D.S.; Yun, S.S.; Kim, H.J.; Kim, J.H.; Kim, J.R.
Cellular mechanisms of hepatocyte growth factor-mediated urokinase plasminogen activator secretion by MAPK signaling in hepatocellular carcinoma (2008), Tumori, 94, 523-530.

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Activating Compound

Activating Compound	Comment	Organism	Structure
SB 203580	pretreatment of Hep-G2 cells with SB 203580 increases hepatocyte growth factor-mediated uPA secretion by 50-60%	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	stable expression of dominant-negative MEK-1 in Hep-G2 cells decreases S hepatocyte growth factor-mediated uPA secretion	Homo sapiens
PD 098059	hepatocyte growth factor-mediated uPA secretion by Hep-G2 cells is reduced with increasing concentrations of PD 098059	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEP-3B cell	-	Homo sapiens	-
Hep-G2 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)