Literature summary for 3.4.21.73 extracted from

Kumano, M.; Miyake, H.; Muramaki, M.; Furukawa, J.; Takenaka, A.; Fujisawa, M.
Expression of urokinase-type plasminogen activator system in prostate cancer: correlation with clinicopathological outcomes in patients undergoing radical prostatectomy (2009), Urol. Oncol., 27, 180-186.

Search for more literature for 3.4.21.73

Application

Application	Comment	Organism
diagnostics	expression level of uPA in prostate cancer tissue can be used as a predictor of biochemical recurrence in patients undergoing radical prostatectomy, i.e. strong expression of uPA in addition to a Gleason score, positive surgical margin, and lymph node metastasis	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
plasminogen activator inhibitor-1	PAI-1	Homo sapiens
plasminogen activator inhibitor-2	PAI-2	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	uPA, uPA receptor, and plasminogen activator inhibitor form the urokinase-type plasminogen activator system	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	strong expression of uPA in addition to a Gleason score, positive surgical margin, and lymph node metastasis	Homo sapiens	-
prostate cancer cell	expression levels of urokinase-type plasminogen activator system in radical prostatectomy specimens, overview	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	uPA, uPA receptor, and plasminogen activator inhibitor form the urokinase-type plasminogen activator system	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
uPA	-	Homo sapiens
Urokinase-type plasminogen activator	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)