Inhibitors | Comment | Organism | Structure |
---|---|---|---|
plasminogen activator inhibitor 1 | - |
Homo sapiens | |
Plasminogen activator inhibitor 2 | - |
Homo sapiens | |
Protease nexin I | - |
Homo sapiens | |
Protein C inhibitor | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
plasmin, plasma kallikrein, trypsin, thermolysin and cathepsin B and L cleave pro-uPA at the peptide bond Lys158-Ile159 which converts pro-uPA into the enzymatically active high-molecular weight two-chain form | Homo sapiens |
52000 | - |
human, high-molecular weight two-chain form | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | Homo sapiens | the enzyme mediates pericellular proteolysis during cell migration and tissue remodelling under physiological and pathophysiological conditions | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
alveolar cell | - |
Homo sapiens | - |
fibroblast | - |
Homo sapiens | - |
keratinocyte | - |
Homo sapiens | - |
kidney | tubule cells | Homo sapiens | - |
phagocyte | granulocytes, monocytes | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | - |
Homo sapiens | plasmin + ? | - |
? | |
plasminogen + H2O | the enzyme mediates pericellular proteolysis during cell migration and tissue remodelling under physiological and pathophysiological conditions | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the two-polypeptide of the high-molecular-weight two-chain form are linked by disulfide bonds | Homo sapiens |
More | A-chain MW 20000 and B-chain MW 32000 | Homo sapiens |