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Literature summary for 3.4.21.73 extracted from

  • Schmitt, M.; Jänicke, F.; Moniwa, N.; Chucholowski, N.; Pache, L.; Graeff, H.
    Tumor-associated urokinase-type plasminogen activator: biological and clinical significance (1992), Biol. Chem. Hoppe-Seyler, 373, 611-622.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
plasminogen activator inhibitor 1
-
Homo sapiens
Plasminogen activator inhibitor 2
-
Homo sapiens
Protease nexin I
-
Homo sapiens
Protein C inhibitor
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
plasmin, plasma kallikrein, trypsin, thermolysin and cathepsin B and L cleave pro-uPA at the peptide bond Lys158-Ile159 which converts pro-uPA into the enzymatically active high-molecular weight two-chain form Homo sapiens
52000
-
human, high-molecular weight two-chain form Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
plasminogen + H2O Homo sapiens the enzyme mediates pericellular proteolysis during cell migration and tissue remodelling under physiological and pathophysiological conditions ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
alveolar cell
-
Homo sapiens
-
fibroblast
-
Homo sapiens
-
keratinocyte
-
Homo sapiens
-
kidney tubule cells Homo sapiens
-
phagocyte granulocytes, monocytes Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
plasminogen + H2O
-
Homo sapiens plasmin + ?
-
?
plasminogen + H2O the enzyme mediates pericellular proteolysis during cell migration and tissue remodelling under physiological and pathophysiological conditions Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
More the two-polypeptide of the high-molecular-weight two-chain form are linked by disulfide bonds Homo sapiens
More A-chain MW 20000 and B-chain MW 32000 Homo sapiens