Literature summary for 3.4.21.73 extracted from

Miyake, K.; Shimada, M.; Nishioka, M.; Sugimoto, K.; Batmunkh, E.; Uto, Y.; Nagasawa, H.; Hori, H.
Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer (2009), Cancer Chemother. Pharmacol., 64, 885-892.

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Application

Application	Comment	Organism
pharmacology	Treatment of nude mice bearing subcutaneously or orthotopically implanted human colon cancer cell lines HCT-116 and HT-29 with TX-1877, irradiation or TX-1877 with irradiation results in significant inhibition of matrix metalloproteinase-9 and uPA. Treatments also inhibit the para-aortic lymph node metastasis, however, do not prolong the survival in orthotopic model. In the subcutaneous model, tumors treated with TX-1877 and irradiation show significant reductions in volume	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
TX-1877	hypoxic cell radiosensitizer. Treatment of nude mice bearing subcutaneously or orthotopically implanted human colon cancer cell lines HCT-116 and HT-29 with TX-1877, irradiation or TX-1877 with irradiation results in significant inhibition of matrix metalloproteinase-9 and uPA. Treatments also inhibit the para-aortic lymph node metastasis, however, do not prolong the survival in orthotopic model. In the subcutaneous model, tumors treated with TX-1877 and irradiation show significant reductions in volume	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HCT-116 cell	implanted subcutaneously or orthotopically to nude mice	Homo sapiens	-
HT-29 cell	implanted subcutaneously or orthotopically to nude mice	Homo sapiens	-

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Release 2023.1 (January 2023)