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Literature summary for 3.4.21.73 extracted from

  • Cheng, C.Y.; Hsieh, H.L.; Sun, C.C.; Lin, C.C.; Luo, S.F.; Yang, C.M.
    IL-1 beta induces urokinase-plasminogen activator expression and cell migration through PKC alpha, JNK1/2, and NF-kappaB in A549 cells (2009), J. Cell. Physiol., 219, 183-193.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
interleukin beta significantly induces uPA expression and activity via protein kinase Calpha-dependent JNK1/2 and NIK cascades. Induction is inhibited by pretreatment with the inhibitors of JNK1/2, SP600125, of protein kinase C, Ro31-8220 and Go6976, or of nuclear factor kappaB, helenalin, and by transfection with dominant negative mutants of protein kinase C alpha, NIK, and IKKbeta, and siRNAs of JNK1/2 and p65 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
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Homo sapiens
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