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3.4.21.73: u-Plasminogen activator

This is an abbreviated version!
For detailed information about u-Plasminogen activator, go to the full flat file.

Word Map on EC 3.4.21.73

Reaction

Specific cleavage of Arg-/-Val bond in plasminogen to form plasmin =

Synonyms

Abbokinase, Cellular plasminogen activator, Double-chain urokinase-type plasminogen activator, EC 3.4.21.31, EC 3.4.99.26, Plasminogen activator, urokinase-type, PLAU, Two-chain urokinase-type plasminogen activator, u-PA, U-plasminogen activator, UK, uPA, uPA-type Plg activator, Urinary esterase A, Urinary plasminogen activator, Urokinase, Urokinase plasminogen activator, urokinase type plasminogen activator, urokinase-plasminogen activator, urokinase-type PA, urokinase-type plasmin activator, urokinase-type plasminogen, Urokinase-type plasminogen activator, urokinase-type Plg activator, urokine-type plasminogen activator

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.73 u-Plasminogen activator

Purification

Purification on EC 3.4.21.73 - u-Plasminogen activator

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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
high-molecular weight uPA expressed in SP2/0 cell culture
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recombinant enzyme
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recombinant isolated kringle domain UK1 from Pichia pastoris
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recombinant mutant enzyme by dialysis and ultrafiltration
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recombinant mutant S195A from Pichia pastoris strain X-33 by nickel affinity chromatography and gel filtration
recombinant uPA from S2 cells by immunoaffinity chromatography
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recombinant wild-type enzyme by dialysis and ultrafiltration
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