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Literature summary for 3.4.21.73 extracted from

  • Sanderson-Smith, M.L.; Zhang, Y.; Ly, D.; Donahue, D.; Hollands, A.; Nizet, V.; Ranson, M.; Ploplis, V.A.; Walker, M.J.; Castellino, F.J.
    A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection (2013), PLoS Pathog., 9, e1003469.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.73

Protein Variants

Protein Variants Comment Organism
additional information generation of strain AlbPLG1/uPA-/- enzyme-deficient mice Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
plasminogen + H2O Homo sapiens
-
 plasmin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P00749
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification activation of enzyme zymogen. Group A Streptococci are able to mediate a significant increase in the activation of zymogen pro-enzyme in human plasma. The zymogen pro-uPA can be activated by a variety of proteases, including plasmin Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
plasminogen + H2O
-
 Homo sapiens plasmin + ?
-
 ?

Synonyms

Synonyms Comment Organism
uPA
-
 Homo sapiens
Urokinase-type plasminogen activator
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction both C57/black 6J, and AlbPLG1 mice expressing the human plasminogen transgene, are significantly more susceptible to invasive Group A Streptococcus strain 5448 disease than enzyme-deficient uPA-/- mice. The observed decrease in virulence in uPA-/- mice correlates directly with a decrease in bacterial dissemination and reduced cell surface plasmin accumulation by Group A Streptococci Homo sapiens
physiological function the enzyme is primarily involved in cell-associated plasminogen activation. Urokinase-type plasminogen activator contributes to plasmin recruitment and subsequent invasive disease initiation by invasive Group A streptococci in vivo, it hhas a key role in cell surface plasmin acquisition and bacterial dissemination in invasive Group A streptococcus disease Homo sapiens