Literature summary for 3.4.21.73 extracted from

Biermann, J.C.; Holzscheiter, L.; Kotzsch, M.; Luther, T.; Kiechle-Bahat, M.; Sweep, F.C.; Span, P.N.; Schmitt, M.; Magdolen, V.
Quantitative RT-PCR assays for the determination of urokinase-type plasminogen activator and plasminogen activator inhibitor type 1 mRNA in primary tumor tissue of breast cancer patients: comparison to antigen quantification by ELISA (2008), Int. J. Mol. Med., 21, 251-259.

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Application

Application	Comment	Organism
analysis	quantification of uPA and inhibitor PAI-1 mRNA expression in breast cancer cell lines as well as in tumor tissue of breast cancer patients by sensitive quantitative real-time PCR assays, based on the LightCycler technology. In breast cancer cell lines, mRNA and antigen values are highly correlated for both uPA and PAI-1 I. Correlations between uPA/PAI-1 mRNA and protein in the breast cancer samples were found to be distinctly weaker or not significant. Quantitative determination of mRNA expression for both factors does not mirror antigen levels in breast cancer tissue	Homo sapiens
medicine	quantification of uPA and inhibitor PAI-1 mRNA expression in breast cancer cell lines as well as in tumor tissue of breast cancer patients by sensitive quantitative real-time PCR assays, based on the LightCycler technology. In breast cancer cell lines, mRNA and antigen values are highly correlated for both uPA and PAI-1 I. Correlations between uPA/PAI-1 mRNA and protein in the breast cancer samples were found to be distinctly weaker or not significant. Quantitative determination of mRNA expression for both factors does not mirror antigen levels in breast cancer tissue	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HaCaT cell	-	Homo sapiens	-
MCF-7 cell	-	Homo sapiens	-
MCF-7 cell	adriamycine-resistant subline of MCF-7	Homo sapiens	-
MDA-MB-231 cell	-	Homo sapiens	-
MDA-MB-231-BAG cell	subline of MDA-MB-231, stably transfected with the bacterial lacZ gene	Homo sapiens	-
MDA-MB-435 cell	-	Homo sapiens	-
OV-MZ-10 cell	-	Homo sapiens	-
OV-MZ-6 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)