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Literature summary for 3.4.21.73 extracted from

  • Sandra, D.; Radha, M.; Harishkumar, M.; Yuichi, N.; Sayuri, O.; Masugi, M.
    Downregulation of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 by grape seed proanthocyanidin extract (2010), Phytomedicine, 17, 42-46.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
plasminogen activator inhibitor-1 i.e. PAI-1 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
plasminogen + H2O Homo sapiens
-
plasmin + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
Homo sapiens
-
fibroblast
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
plasminogen + H2O
-
Homo sapiens plasmin + ?
-
?

Synonyms

Synonyms Comment Organism
uPA
-
Homo sapiens
Urokinase plasminogen activator
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens uPA and its endogenous inhibitor PAI-1 are downregulated by grape seed, Vitis ssp., proanthocyanidin extract, both at the RNA and protein levels, due to the extract's antioxidant activity down

General Information

General Information Comment Organism
physiological function the urokinase plasminogen activator, uPA, system, comprising of uPA, its receptor uPAR and inhibitor, type 1 plasminogen activator inhibitor, PAI-1, plays a vital role in various biological processes involving extracellular proteolysis, fibrinolysis, cell migration and proliferation Homo sapiens