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Literature summary for 3.4.21.73 extracted from

  • Asuthkar, S.; Stepanova, V.; Lebedeva, T.; Holterman, A.L.; Estes, N.; Cines, D.B.; Rao, J.S.; Gondi, C.S.
    Multifunctional roles of urokinase plasminogen activator (uPA) in cancer stemness and chemoresistance of pancreatic cancer (2013), Mol. Biol. Cell, 24, 2620-2632.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P00749
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MiaPaCa-2 cell
-
 Homo sapiens
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PANC-1 cell
-
 Homo sapiens
-
serum
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
uPA
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 Homo sapiens
Urokinase plasminogen activator
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction suppression of uPA retards development of pancreatic cancer in nude mice and increases sensitization to gemcitabine Homo sapiens
metabolism a poor prognosis of pancreatic ductal adenocarcinoma is correlated with increased expression of urokinase plasminogen activator Homo sapiens
physiological function role of the enzyme in pancreatic ductal adenocarcinoma cancer stem cells, a large fraction of these side population cells are CD44 and CD24 positive, are gemcitabine resistant, possess sphere-forming ability, and exhibit increased tumorigenic­ity. The enzyme interacts directly with tran­scription factors LIM homeobox-2 (Lhx2), homeobox transcription factor A5 (HOXA5), and Hey to possibly promote cancer stemness. The enzyme regulates Lhx2 expression by suppressing expression of miR-124 and p53 expression by repressing its promoter by inactivating HOXA5. Regulation of gene transcription by the enzyme contributes to cancer stemness and clinical lethality Homo sapiens