Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Mus musculus | - |
- |
extracellular | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00749 | - |
- |
Mus musculus | - |
- |
- |
Mus musculus C57BL/6 | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Mus musculus | - |
blood plasma | - |
Homo sapiens | - |
macrophage | enzyme expression in atherosclerotic lesion macrophages | Mus musculus | - |
macrophage | enzyme expression in atherosclerotic lesion macrophages | Homo sapiens | - |
monocyte | - |
Mus musculus | - |
monocyte | - |
Homo sapiens | - |
THP-1 cell | myeloid leukemia cell line | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
uPA | - |
Mus musculus |
uPA | - |
Homo sapiens |
Urokinase-type plasminogen activator | - |
Mus musculus |
Urokinase-type plasminogen activator | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | in enzyme knockout mice, the number of peritoneal macrophages is lower by 30% than the peritoneal macrophages harvested from wild-type C57BL/6 mice | Mus musculus |
physiological function | the enzyme modulates monocyte-to-macrophage differentiation and prevents oxidized LDL-induced macrophage apoptosis via ERK1/2 activation-dependent Bim downregulation, mechanism, overview. Monocyte-to-macrophage differentiation and macrophage death play a pivotal role in atherogenesis. The enzyme and its receptor uPAR are expressed in atherosclerotic lesion macrophages and contribute to atherosclerosis progression | Mus musculus |
physiological function | the enzyme modulates monocyte-to-macrophage differentiation and prevents oxidized LDL-induced macrophage apoptosis via ERK1/2 activation-dependent Bim downregulation, mechanism, overview. The enzyme attenuates MonoMac6 macrophage-like cell line apoptosis (with maximal inhibition of 51% by 5 nmol/l of enzyme) induced by oxidized LDL and by thapsigargin (inhibitor of sarcoendoplasmic reticulum Ca2รพ-ATPase), but not by staurosporine (protein kinase inhibitor), suggesting that the enzyme's antiapoptotic activity is Ca2+-independent, but involves a kinase activation. Monocyte-to-macrophage differentiation and macrophage death play a pivotal role in atherogenesis. The enzyme and its receptor uPAR are expressed in atherosclerotic lesion macrophages and contribute to atherosclerosis progression. The enzyme attenuates endoplasmatic reticulum stress-induced cell death, overview | Homo sapiens |