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Literature summary for 3.4.21.73 extracted from

  • Paland, N.; Aharoni, S.; Fuhrman, B.
    Urokinase-type plasminogen activator (uPA) modulates monocyte-to-macrophage differentiation and prevents Ox-LDL-induced macrophage apoptosis (2013), Atherosclerosis, 231, 29-38.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
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Mus musculus
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extracellular
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Homo sapiens
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Organism

Organism UniProt Comment Textmining
Homo sapiens P00749
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Mus musculus
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-
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Mus musculus C57BL/6
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-
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Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
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Mus musculus
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blood plasma
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Homo sapiens
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macrophage enzyme expression in atherosclerotic lesion macrophages Mus musculus
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macrophage enzyme expression in atherosclerotic lesion macrophages Homo sapiens
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monocyte
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Mus musculus
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monocyte
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Homo sapiens
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THP-1 cell myeloid leukemia cell line Homo sapiens
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Synonyms

Synonyms Comment Organism
uPA
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Mus musculus
uPA
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Homo sapiens
Urokinase-type plasminogen activator
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Mus musculus
Urokinase-type plasminogen activator
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Homo sapiens

General Information

General Information Comment Organism
malfunction in enzyme knockout mice, the number of peritoneal macrophages is lower by 30% than the peritoneal macrophages harvested from wild-type C57BL/6 mice Mus musculus
physiological function the enzyme modulates monocyte-to-macrophage differentiation and prevents oxidized LDL-induced macrophage apoptosis via ERK1/2 activation-dependent Bim downregulation, mechanism, overview. Monocyte-to-macrophage differentiation and macrophage death play a pivotal role in atherogenesis. The enzyme and its receptor uPAR are expressed in atherosclerotic lesion macrophages and contribute to atherosclerosis progression Mus musculus
physiological function the enzyme modulates monocyte-to-macrophage differentiation and prevents oxidized LDL-induced macrophage apoptosis via ERK1/2 activation-dependent Bim downregulation, mechanism, overview. The enzyme attenuates MonoMac6 macrophage-like cell line apoptosis (with maximal inhibition of 51% by 5 nmol/l of enzyme) induced by oxidized LDL and by thapsigargin (inhibitor of sarcoendoplasmic reticulum Ca2รพ-ATPase), but not by staurosporine (protein kinase inhibitor), suggesting that the enzyme's antiapoptotic activity is Ca2+-independent, but involves a kinase activation. Monocyte-to-macrophage differentiation and macrophage death play a pivotal role in atherogenesis. The enzyme and its receptor uPAR are expressed in atherosclerotic lesion macrophages and contribute to atherosclerosis progression. The enzyme attenuates endoplasmatic reticulum stress-induced cell death, overview Homo sapiens