5.6.1.1: microtubule-severing ATPase This is an abbreviated version! For detailed information about microtubule-severing ATPase, go to the full flat file .
Reaction
n ATP
+
n H2O
+
a microtubule =
n ADP
+
n phosphate
+
(n+1) alpha/beta tubulin heterodimers
Synonyms adseverin, Arabidopsis thaliana katanin small subunit, AtKSS, D-spastin, DGL1, Dm-Kat60, Drosophila katanin Dm-Kat60, EC 3.6.4.3, kananin, Kat60, katanin, KATANIN 1, katanin p60, katanin p60 ATPase-containing subunit A1, katanin p60 microtubule-severing protein, KATNAL1, kinesin spindle protein, kp60-NTD, KSP, mei-1, MEI-1/MEI-2 complex, MEI-1/MEI-2 katanin complex, microtuble severing AAA ATPase spastin, microtuble-severing AAA ATPase, microtuble-severing ATPase spastin, microtubule severing protein, microtubule-severing AAA ATPase, microtubule-severing ATPase, microtubule-severing complex katanin, microtubule-severing complex MEI-1/MEI-2 katanin, microtubule-severing protein, microtubule-stimulated ATPase, MT-severing AAA ATPase, P60, p60 KAT1p, p60 katanin, P60-kananin, P60-katanin, p81-p60, Pf15, plant microtubule-severing protein, rice KTN1, scinderin, SPAS-1, spastin, spastin AAA domain, SPG4, Sug1p, vertebrate katanin
ECTree
Natural Substrates Products
Natural Substrates Products on EC 5.6.1.1 - microtubule-severing ATPase
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ATP + H2O
ADP + phosphate
ATP + H2O + microtubule
ADP + phosphate + alpha/beta tubulin heterodimers
GTP + H2O
GDP + phosphate
additional information
?
-
ATP + H2O
ADP + phosphate
Actinocoryne sp.
-
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
ir
ATP + H2O
ADP + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
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ir
ATP + H2O
ADP + phosphate
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-
-
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?
ATP + H2O
ADP + phosphate
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
ir
ATP + H2O
ADP + phosphate
Drosophila sp. (in: flies)
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-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
-
ir
ATP + H2O
ADP + phosphate
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-
-
?
ATP + H2O
ADP + phosphate
-
-
-
ir
ATP + H2O
ADP + phosphate
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
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-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
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-
?
ATP + H2O
ADP + phosphate
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-
-
-
?
ATP + H2O + microtubule
ADP + phosphate + alpha/beta tubulin heterodimers
assembly of female meiotic spindles requires MEI-1 and MEI-2, which constitute the microtubule-severing AAA+ ATPase Katanin
-
-
?
ATP + H2O + microtubule
ADP + phosphate + alpha/beta tubulin heterodimers
-
-
-
?
ATP + H2O + microtubule
ADP + phosphate + alpha/beta tubulin heterodimers
the enzyme plays important roles in various cellular events including axon regeneration, cytokinesis, and nuclear envelope sealing after mitosis
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-
?
ATP + H2O + microtubule
ADP + phosphate + alpha/beta tubulin heterodimers
-
katanin-dependent severing of microtubules is important for proper execution of key cellular activities including cell division, migration, and differentiation
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-
?
ATP + H2O + microtubule
ADP + phosphate + alpha/beta tubulin heterodimers
-
katanin-dependent severing of microtubules is important for proper execution of key cellular activities including cell division, migration, and differentiation
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-
?
GTP + H2O
GDP + phosphate
Actinocoryne sp.
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-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
-
?
GTP + H2O
GDP + phosphate
Drosophila sp. (in: flies)
-
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
-
?
additional information
?
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-
direct role of microtubule severing in translocation of the meiotic spindle to the cortex
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-
?
additional information
?
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-
enzyme acts on defects in microtubule lattice, promotes loss of tubulin at the defect site until the two microtubule segments are held together so weakly that mechanically unconstrained microtubules kink at the defect site
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-
?
additional information
?
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enzyme activity regulates the number of microtubule end in mitotic spindle, enzyme inhibition slows the rate of spindle microtubule disassembly
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-
?
additional information
?
-
katanin p60 destabilizes microtubules at the central spindle and the midbody
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-
?