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evolution
the enzyme is a member of a family of AAA+ ATPases (ATPase associated with various cellular activities)
malfunction
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mutations identified as a major cause of a genetic neurodegenerative condition termed hereditary spastic paraplegia
malfunction
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point mutations or exon deletions in the microtubule-severing ATPase, spastin, are responsible for approximately 40% of cases of autosomal dominant hereditary spastic paraplegia
malfunction
inhibition of katanin p60 results in incomplete cytokinesis by regression and thus caused the appearance of binucleate cells
malfunction
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rapid inactivation of katanin results in complete loss of ASPM-1 positive spindle poles. Strong loss-of-function mutants assemble apolar intersecting microtubule arrays, whereas weaker mutants assemble bipolar meiotic spindles that are longer than wild-type. Microtubule disassembly in enzyme point mutants, overview. Progressive loss of katanin leads to a progressive loss in the organization of pole-to-pole microtubule bundles, phenotypes
malfunction
cells overexpressing Kat60 display a disorganized array of fragmented microtubules and the overall length of microtubules appears to decrease with increasing levels of Kat60. Depletion of catalytic subunit Kat60 and regulatory subunit Kat80 causes minimal perturbation of steady-state alpha-tubulin levels in cells
malfunction
KATANIN 1 mutants, fra2, lue1 and ktn1-2 collectively display lower fertility and seed set in Arabidopsis. The lower fertility and seed set rates of fra2, lue1 and ktn1-2 mutants are correlated to abnormalities in the development of embryo proper and seed
malfunction
variants show disorganized microtubules that lack focused spindle poles reminiscent of the Katanin loss-of-function phenotype, demonstrating that the microtubule-severing activity is essential for meiotic spindle assembly in Caenorhabditis elegans
malfunction
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KATANIN 1 mutants, fra2, lue1 and ktn1-2 collectively display lower fertility and seed set in Arabidopsis. The lower fertility and seed set rates of fra2, lue1 and ktn1-2 mutants are correlated to abnormalities in the development of embryo proper and seed
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physiological function
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katanin p60, a microtubule-severing enzyme plays a key role in cytoskeletal reorganization during various cellular events in an ATP-dependent manner
physiological function
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SPAS-1 shows microtubule-severing activity when expresses in cultured cells. When alpha/beta tubulin dimer is incubated with SPAS-1, tubulin is pulled down with SPAS-1, suggesting the Caenorhabditis elegans SPAS-1 binds to tubulin
physiological function
functional experiments indicate that spastin depletion results in reduced cell motility and higher cell proliferation of glioblastoma cell line T98G cells
physiological function
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important for motoneuron integrity
physiological function
katanin is a microtubule-severing protein comprised of an AAA+ ATPase subunit and an accessory subunit designated as p60 and p80, respectively. Katanin p60 (ATPase-containing) subunit A1 does not bind with p80 at the midzone or midbody, and localization depends on microtubules. At the central spindle and the midbody, no microtubule growth plus termini are seen with katanin p60, and microtubule density is inversely correlated with katanin p60 density in the region of katanin p60 localization that seems to lead to microtubule destabilization at the midbody. Katanin p60 contributes to microtubule instability at the midzone and midbody and facilitates cytokinesis in rat cells, microtubule destabilization function of katanin p60 at the midzone and the midbody during cell division contributing to accurate cytokinesis
physiological function
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katanin maintains meiotic metaphase chromosome alignment and spindle structure in vivo. Assembly of Caenorhabditis elegans female meiotic spindles requires both MEI-1 and MEI-2 subunits of the microtubule-severing ATPase katanin. A linear relationship between in vitro microtubule disassembly rates and in vivo spindle length exists
physiological function
assembly of female meiotic spindles requires MEI-1 and MEI-2, which constitute the microtubule-severing AAA+ ATPase Katanin
physiological function
Katanin A subunit catalyzes the microtubule-severing activity during mitosis. It likely coordinates with KATNB1 to perform this function. KATNBL1 is a regulator of mammalian Katanin microtubule-severing
physiological function
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katanin is a negative regulator of microtubule minus-end stabilization by CAMSAPs proteins
physiological function
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katanin-dependent severing of microtubules is important for proper execution of key cellular activities including cell division, migration, and differentiation
physiological function
reduction in KATANIN expression inhibits formation of adventitious roots and indirectly influences the specific expression of some microtubule-associated proteins
physiological function
the enzyme fulfills a major regulatory mechanism of dynamic microtubule turnover in eukaryotes. It is essential for embryogenesis and seed formation in Arabidopsis
physiological function
the enzyme plays important roles in various cellular events including axon regeneration, cytokinesis, and nuclear envelope sealing after mitosis
physiological function
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katanin-dependent severing of microtubules is important for proper execution of key cellular activities including cell division, migration, and differentiation
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physiological function
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the enzyme fulfills a major regulatory mechanism of dynamic microtubule turnover in eukaryotes. It is essential for embryogenesis and seed formation in Arabidopsis
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physiological function
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reduction in KATANIN expression inhibits formation of adventitious roots and indirectly influences the specific expression of some microtubule-associated proteins
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