Literature summary for 5.6.1.1 extracted from

Wood, J.D.; Landers, J.A.; Bingley, M.; McDermott, C.J.; Thomas-McArthur, V.; Gleadall, L.J.; Shaw, P.J.; Cunliffe, V.T.
The microtubule-severing protein Spastin is essential for axon outgrowth in the zebrafish embryo (2006), Hum. Mol. Genet., 15, 2763-2771.

Search for more literature for 5.6.1.1

Application

Application	Comment	Organism
medicine	mutations in the SPG4 gene, spastin is the SPG4 gene product, are the most common cause of autosomal dominant hereditary spastic paraplegia, HSP	Danio rerio

Cloned(Commentary)

Cloned (Comment)	Organism
TA-cloned for sequencing, subcloned into pFLAG-CMV-6a for transfection of HEK293 cells	Danio rerio

Inhibitors

Inhibitors	Comment	Organism	Structure
spg4atg1	morpholino antisense oligonucleotide for blocking translation of spg4 mRNA	Danio rerio
spg4exon7	morpholino antisense oligonucleotide for blocking correct splicing of spg4 mRNA	Danio rerio

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O	Danio rerio	-	ADP + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Danio rerio	Q6NW58	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuron	-	Danio rerio	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O	-	Danio rerio	ADP + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
microtubule severing protein	shares homology with katanin	Danio rerio
spastin	-	Danio rerio

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Release 2023.1 (January 2023)