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Literature summary for 5.6.1.1 extracted from
- Katanin, the microtubule-severing ATPase, is concentrated at centrosomes (1996), J. Cell Sci., 109, 561-567.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| centrosome | - |
Xenopus laevis | 5813 | - |
| centrosome | - |
Strongylocentrotus purpuratus | 5813 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 60000 | - |
1 * 81000 + 1 * 60000, SDS-PAGE | Xenopus laevis |
| 81000 | - |
1 * 81000 + 1 * 60000, SDS-PAGE | Xenopus laevis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | Xenopus laevis | - |
ADP + phosphate | - |
? |  |
| ATP + H2O | Strongylocentrotus purpuratus | - |
ADP + phosphate | - |
? | |
| GTP + H2O | Xenopus laevis | - |
GDP + phosphate | - |
? | |
| GTP + H2O | Strongylocentrotus purpuratus | - |
GDP + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Strongylocentrotus purpuratus | - |
sea urchin | - |
| Xenopus laevis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Xenopus laevis |
- |
Strongylocentrotus purpuratus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers | another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome | Xenopus laevis | |
| n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers | another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome | Strongylocentrotus purpuratus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| egg | - |
Xenopus laevis | - |
| egg | unfertilized | Strongylocentrotus purpuratus | - |
| embryo | - |
Strongylocentrotus purpuratus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | - |
Xenopus laevis | ADP + phosphate | - |
? | |
| ATP + H2O | - |
Strongylocentrotus purpuratus | ADP + phosphate | - |
? | |
| GTP + H2O | - |
Xenopus laevis | GDP + phosphate | - |
? | |
| GTP + H2O | - |
Strongylocentrotus purpuratus | GDP + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Strongylocentrotus purpuratus |
| dimer | 1 * 81000 + 1 * 60000, SDS-PAGE | Xenopus laevis |
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