5.6.1.1: microtubule-severing ATPase

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For detailed information about microtubule-severing ATPase, go to the full flat file.

Word Map on EC 5.6.1.1

5.6.1.1

spastic

hereditary

kinesins

paraplegia

mitotic

cortical

cytoskeleton

disassembly

centrosome

gelsolin

corticospinal

atpases

cytokine

paraparesis

atlastin

microtubule-based

actin-binding

microtubule-binding

escrt-iii

antimitotic

axonopathy

minus-ends

gamma-tubulin

kinesin-related

plus-ends

mt-associated

microtubule-dependent

phragmoplasts

midbody

medicine

Reaction

n ATP + n H2O +

= n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers

Synonyms

adseverin, Arabidopsis thaliana katanin small subunit, AtKSS, D-spastin, DGL1, Dm-Kat60, Drosophila katanin Dm-Kat60, EC 3.6.4.3, kananin, Kat60, katanin, KATANIN 1, katanin p60, katanin p60 ATPase-containing subunit A1, katanin p60 microtubule-severing protein, KATNAL1, kinesin spindle protein, kp60-NTD, KSP, mei-1, MEI-1/MEI-2 complex, MEI-1/MEI-2 katanin complex, microtuble severing AAA ATPase spastin, microtuble-severing AAA ATPase, microtuble-severing ATPase spastin, microtubule severing protein, microtubule-severing AAA ATPase, microtubule-severing ATPase, microtubule-severing complex katanin, microtubule-severing complex MEI-1/MEI-2 katanin, microtubule-severing protein, microtubule-stimulated ATPase, MT-severing AAA ATPase, P60, p60 KAT1p, p60 katanin, P60-kananin, P60-katanin, p81-p60, Pf15, plant microtubule-severing protein, rice KTN1, scinderin, SPAS-1, spastin, spastin AAA domain, SPG4, Sug1p, vertebrate katanin

ECTree

5 Isomerases

5.6 Isomerases altering macromolecular conformation

5.6.1 Enzymes altering polypeptide conformation or assembly

5.6.1.1 microtubule-severing ATPase

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Results	in table
10	Activating Compound
4640	AA Sequence
13	Application
45	Cloned(Commentary)
8	Crystallization (Commentary)
829	Disease/ Diagnostics
6	Expression
25	General Information
26	IC50 Value
54	Inhibitors
3	Ki Value [mM]
14	KM Value [mM]
51	Localization
3	Metals/Ions
62	Molecular Weight [Da]
107	Natural Substrates/ Products (Substrates)
105	Organism
43	PDB ID
3	pH Optimum
55	Protein Variants
31	Purification (Commentary)
41	Reaction
20	Reaction Type
101	Reference
80	Source Tissue
3	Specific Activity [micromol/min/mg]
124	Substrates and Products (Substrate)
52	Subunits
105	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Stability [°C]
10	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 5.6.1.1 - microtubule-severing ATPase

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3-[[3-(methylsulfanyl)phenyl]amino]-4-[4-(trifluoromethyl)phenyl]-1H-pyrrole-2,5-dione

Homo sapiens

accelerates KSP-catalyzed ATP hydrolysis in the absence of microtubules circa 10fold

687306

microtubule

2 entries

microtubules

Caenorhabditis elegans

SPAS-1's ATPase activity increases with increasing concentrations of microtubules up to 0.00025 mM and then declines at higher microtubule concentrations. In the presence of 0.00025 mM microtubules, ATPase activity is 7times higher than in the absence of microtubules

712104

p80 KAT3p

Tetrahymena thermophila

dual character of p80 KAT3p as both an activator and a repressor of p60 KAT1p

748669

Protein kinase C

Gallus gallus

adseverin upregulation is linked to the chondrocyte maturation program and is regulated by PKC

673239

tubulin

Arabidopsis thaliana

Q9SEX2

at 0.001 mM, up to 6fold stimulation of ATPase activity

654498

additional information

3 entries