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5.6.1.1: microtubule-severing ATPase

This is an abbreviated version!
For detailed information about microtubule-severing ATPase, go to the full flat file.

Word Map on EC 5.6.1.1

Reaction

n ATP + n H2O +

a microtubule
= n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers

Synonyms

adseverin, Arabidopsis thaliana katanin small subunit, AtKSS, D-spastin, DGL1, Dm-Kat60, Drosophila katanin Dm-Kat60, EC 3.6.4.3, kananin, Kat60, katanin, KATANIN 1, katanin p60, katanin p60 ATPase-containing subunit A1, katanin p60 microtubule-severing protein, KATNAL1, kinesin spindle protein, kp60-NTD, KSP, mei-1, MEI-1/MEI-2 complex, MEI-1/MEI-2 katanin complex, microtuble severing AAA ATPase spastin, microtuble-severing AAA ATPase, microtuble-severing ATPase spastin, microtubule severing protein, microtubule-severing AAA ATPase, microtubule-severing ATPase, microtubule-severing complex katanin, microtubule-severing complex MEI-1/MEI-2 katanin, microtubule-severing protein, microtubule-stimulated ATPase, MT-severing AAA ATPase, P60, p60 KAT1p, p60 katanin, P60-kananin, P60-katanin, p81-p60, Pf15, plant microtubule-severing protein, rice KTN1, scinderin, SPAS-1, spastin, spastin AAA domain, SPG4, Sug1p, vertebrate katanin

ECTree

     5 Isomerases
         5.6 Isomerases altering macromolecular conformation
             5.6.1 Enzymes altering polypeptide conformation or assembly
                5.6.1.1 microtubule-severing ATPase

IC50 Value

IC50 Value on EC 5.6.1.1 - microtubule-severing ATPase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00247
3'-fluoro-4'-(trifluoromethyl)biphenyl-4-amine
Homo sapiens
-
-
0.00147
3'-fluoro-4'-(trifluoromethyl)biphenyl-4-carbaldehyde
Homo sapiens
-
-
0.0014
3'-fluoro-4'-(trifluoromethyl)biphenyl-4-carbonitrile
Homo sapiens
-
-
0.00214
3'-fluoro-4'-(trifluoromethyl)biphenyl-4-ol
Homo sapiens
-
-
0.00086
3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl methyl sulfone
Homo sapiens
-
-
0.0037
3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl methyl sulfoxide
Homo sapiens
-
-
0.00461
3'-fluoro-N-methyl-4'-(trifluoromethyl)biphenyl-4-sulfonamide
Homo sapiens
-
-
0.0068
3-(4-tert-butylphenyl)pyridine
Homo sapiens
-
-
0.00714
3-fluoro-4'-(methoxymethyl)-4-(trifluoromethyl)biphenyl
Homo sapiens
-
-
0.00549
4'-(trifluoromethyl)biphenyl-4-carbonitrile
Homo sapiens
-
-
0.00147
4'-tert-butylbiphenyl-4-carbonitrile
Homo sapiens
-
-
0.00042
4-(3-tert-butylphenyl)pyridine
Homo sapiens
-
-
0.001
4-(4-tert-butylphenyl)pyridine
Homo sapiens
-
-
0.00278
N-[3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]methanesulfonamide
Homo sapiens
-
-
0.00002
N-[3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]sulfamide
Homo sapiens
-
-
0.00004
N-[5-[3-fluoro-4-(trifluoromethyl)phenyl]pyridin-2-yl]sulfamide
Homo sapiens
-
-
0.00306
N-[[3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]methyl]sulfamide
Homo sapiens
-
-
0.0007
PVZB1084
Homo sapiens
-
-
0.00012
PVZB1194
Homo sapiens
-
-
0.00363
[3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]methanol
Homo sapiens
-
-
additional information
1-[3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]methanamine