5.6.1.1: microtubule-severing ATPase

This is an abbreviated version!
For detailed information about microtubule-severing ATPase, go to the full flat file.

Reaction

n ATP + n H2O +

Synonyms

adseverin, Arabidopsis thaliana katanin small subunit, AtKSS, D-spastin, DGL1, Dm-Kat60, Drosophila katanin Dm-Kat60, EC 3.6.4.3, kananin, Kat60, katanin, KATANIN 1, katanin p60, katanin p60 ATPase-containing subunit A1, katanin p60 microtubule-severing protein, KATNAL1, kinesin spindle protein, kp60-NTD, KSP, mei-1, MEI-1/MEI-2 complex, MEI-1/MEI-2 katanin complex, microtuble severing AAA ATPase spastin, microtuble-severing AAA ATPase, microtuble-severing ATPase spastin, microtubule severing protein, microtubule-severing AAA ATPase, microtubule-severing ATPase, microtubule-severing complex katanin, microtubule-severing complex MEI-1/MEI-2 katanin, microtubule-severing protein, microtubule-stimulated ATPase, MT-severing AAA ATPase, P60, p60 KAT1p, p60 katanin, P60-kananin, P60-katanin, p81-p60, Pf15, plant microtubule-severing protein, rice KTN1, scinderin, SPAS-1, spastin, spastin AAA domain, SPG4, Sug1p, vertebrate katanin

ECTree

     5 Isomerases

         5.6 Isomerases altering macromolecular conformation

             5.6.1 Enzymes altering polypeptide conformation or assembly

                5.6.1.1 microtubule-severing ATPase

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Results	in table
10	Activating Compound
4640	AA Sequence
13	Application
45	Cloned(Commentary)
8	Crystallization (Commentary)
829	Disease/ Diagnostics
6	Expression
25	General Information
26	IC50 Value
54	Inhibitors
3	Ki Value [mM]
14	KM Value [mM]
51	Localization
3	Metals/Ions
62	Molecular Weight [Da]
107	Natural Substrates/ Products (Substrates)
105	Organism
43	PDB ID
3	pH Optimum
55	Protein Variants
31	Purification (Commentary)
41	Reaction
20	Reaction Type
101	Reference
80	Source Tissue
3	Specific Activity [micromol/min/mg]
124	Substrates and Products (Substrate)
52	Subunits
105	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Stability [°C]
10	Turnover Number [1/s]

Expression

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Expression on EC 5.6.1.1 - microtubule-severing ATPase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

cells induced to express the catalytic subunit Kat60 have reduced levels of alpha-tubulin compared to control cells

Drosophila melanogaster

Q9VN89

749052

expression and cellular distribution are increased in neoplastic glial phenotypes, especially in glioblastoma

Homo sapiens

Q9UBP0

720295

overexpression of both, p80 KAT3p and p60 KAT1p enhances the rate of disassembly of microtubular structures as compared with overexpression of p60 KAT1p alone

2 entries

reduction in KATANIN expression inhibits formation of adventitious roots and indirectly influences the specific expression of some microtubule-associated proteins

2 entries

overexpression of both, p80 KAT3p and p60 KAT1p enhances the rate of disassembly of microtubular structures as compared with overexpression of p60 KAT1p alone

Tetrahymena thermophila

-

748669

overexpression of both, p80 KAT3p and p60 KAT1p enhances the rate of disassembly of microtubular structures as compared with overexpression of p60 KAT1p alone

Tetrahymena thermophila CU428.2

-

-

reduction in KATANIN expression inhibits formation of adventitious roots and indirectly influences the specific expression of some microtubule-associated proteins

Arabidopsis thaliana

Q9SEX2

749069

reduction in KATANIN expression inhibits formation of adventitious roots and indirectly influences the specific expression of some microtubule-associated proteins

Arabidopsis thaliana ecotype Columbia

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