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5.6.1.1: microtubule-severing ATPase

This is an abbreviated version!
For detailed information about microtubule-severing ATPase, go to the full flat file.

Word Map on EC 5.6.1.1

Reaction

n ATP + n H2O +

a microtubule
= n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers

Synonyms

adseverin, Arabidopsis thaliana katanin small subunit, AtKSS, D-spastin, DGL1, Dm-Kat60, Drosophila katanin Dm-Kat60, EC 3.6.4.3, kananin, Kat60, katanin, KATANIN 1, katanin p60, katanin p60 ATPase-containing subunit A1, katanin p60 microtubule-severing protein, KATNAL1, kinesin spindle protein, kp60-NTD, KSP, mei-1, MEI-1/MEI-2 complex, MEI-1/MEI-2 katanin complex, microtuble severing AAA ATPase spastin, microtuble-severing AAA ATPase, microtuble-severing ATPase spastin, microtubule severing protein, microtubule-severing AAA ATPase, microtubule-severing ATPase, microtubule-severing complex katanin, microtubule-severing complex MEI-1/MEI-2 katanin, microtubule-severing protein, microtubule-stimulated ATPase, MT-severing AAA ATPase, P60, p60 KAT1p, p60 katanin, P60-kananin, P60-katanin, p81-p60, Pf15, plant microtubule-severing protein, rice KTN1, scinderin, SPAS-1, spastin, spastin AAA domain, SPG4, Sug1p, vertebrate katanin

ECTree

     5 Isomerases
         5.6 Isomerases altering macromolecular conformation
             5.6.1 Enzymes altering polypeptide conformation or assembly
                5.6.1.1 microtubule-severing ATPase

Inhibitors

Inhibitors on EC 5.6.1.1 - microtubule-severing ATPase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-[3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]methanamine
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2-(4-tert-butylphenyl)pyridine
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3'-fluoro-4'-(trifluoromethyl)biphenyl-4-amine
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3'-fluoro-4'-(trifluoromethyl)biphenyl-4-carbaldehyde
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3'-fluoro-4'-(trifluoromethyl)biphenyl-4-carbonitrile
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3'-fluoro-4'-(trifluoromethyl)biphenyl-4-ol
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3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl methyl sulfone
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3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl methyl sulfoxide
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3'-fluoro-N,N-dimethyl-4'-(trifluoromethyl)biphenyl-4-sulfonamide
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3'-fluoro-N-methyl-4'-(trifluoromethyl)biphenyl-4-sulfonamide
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3-(4-tert-butylphenyl)pyridine
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3-fluoro-4'-(methoxymethyl)-4-(trifluoromethyl)biphenyl
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3-[[3-(methylsulfanyl)phenyl]amino]-4-[4-(trifluoromethyl)phenyl]-1H-pyrrole-2,5-dione
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inhibits microtubule-stimulated ATP hydrolysis by KSP
4'-(ethylsulfonyl)-3-fluoro-4-(trifluoromethyl)biphenyl
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4'-(trifluoromethyl)biphenyl-4-carbonitrile
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4'-tert-butylbiphenyl-4-carbonitrile
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4-(2-tert-butylphenyl)pyridine
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4-(3-tert-butylphenyl)pyridine
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4-(4-tert-butylphenyl)pyridine
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5'-adenylyl-beta,gamma-imidodiphosphate
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purley competitive inhibitor
ATPgammaS
Ca2+
inhibits microtuble severing activity
ispinesib
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SB-715992
methyl 3'-fluoro-4'-(trifluoromethyl)biphenyl-4-carboxylate
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N-[3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]methanesulfonamide
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N-[3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]sulfamide
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N-[5-[3-fluoro-4-(trifluoromethyl)phenyl]pyridin-2-yl]sulfamide
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N-[[3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]methyl]sulfamide
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p80 KAT3p
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dual character of p80 KAT3p as both an activator and a repressor of p60 KAT1p
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protein tau
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affords protection of microtubules in katanin-overexpressing neurons
PVZB1084
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PVZB1194
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inhibition only in presence of microtubules
sb26
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mutation in the tbb-2 beta-tubulin gene that partially inhibits MEI-1/MEI-2 activity
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spastin
the basal ATPase activity of spastin is negatively regulated by spastin concentration
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spg4atg1
morpholino antisense oligonucleotide for blocking translation of spg4 mRNA
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spg4exon7
morpholino antisense oligonucleotide for blocking correct splicing of spg4 mRNA
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Tau
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affords some protection of microtubules in spastin-overexpressing neurons
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tubulin
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[3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]methanol
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additional information
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