BRENDA - Enzyme Database
show all sequences of 5.6.1.1

The C. elegans homologue of the spastic paraplegia protein, spastin, disassembles microtubules

Matsushita-Ishiodori, Y.; Yamanaka, K.; Ogura, T.; Biochem. Biophys. Res. Commun. 359, 157-162 (2007)

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
into the TOPO TA cloning vector, into the plasmid pPD49.26
Caenorhabditis elegans
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoskeleton
cytoskeleton at the perinuclear region
Caenorhabditis elegans
5856
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
50000
-
SPAS-1S, consists of eight exons, determined by SDS-PAGE and Western blotting
Caenorhabditis elegans
57000
-
SPAS-1L, consists of nine exons, determined by SDS-PAGE and Western blotting
Caenorhabditis elegans
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
ATP + H2O
Caenorhabditis elegans
-
ADP + phosphate
-
-
ir
Organism
Organism
UniProt
Commentary
Textmining
Caenorhabditis elegans
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
ATP + H2O
-
684854
Caenorhabditis elegans
ADP + phosphate
-
-
-
ir
Synonyms
Synonyms
Commentary
Organism
SPAS-1
-
Caenorhabditis elegans
spastin
-
Caenorhabditis elegans
Cloned(Commentary) (protein specific)
Commentary
Organism
into the TOPO TA cloning vector, into the plasmid pPD49.26
Caenorhabditis elegans
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoskeleton
cytoskeleton at the perinuclear region
Caenorhabditis elegans
5856
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
50000
-
SPAS-1S, consists of eight exons, determined by SDS-PAGE and Western blotting
Caenorhabditis elegans
57000
-
SPAS-1L, consists of nine exons, determined by SDS-PAGE and Western blotting
Caenorhabditis elegans
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
ATP + H2O
Caenorhabditis elegans
-
ADP + phosphate
-
-
ir
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
ATP + H2O
-
684854
Caenorhabditis elegans
ADP + phosphate
-
-
-
ir
Other publictions for EC 5.6.1.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
747780
Fan
The AAA protein spastin posse ...
Homo sapiens
FEBS Lett.
592
1625-1633
2018
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748228
Nithianantham
Structural basis for disassem ...
Caenorhabditis elegans, Homo sapiens
J. Biol. Chem.
293
10590-10605
2018
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2
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749386
Jiang
Structural basis of formation ...
Mus musculus
Structure
26
375-382.e4
2018
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1
1
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747882
Luptovciak
KATANIN 1 is essential for em ...
Arabidopsis thaliana, Arabidopsis thaliana ecotype Columbia
Front. Plant Sci.
8
728
2017
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2
2
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748669
Waclawek
Regulation of katanin activit ...
Tetrahymena thermophila, Tetrahymena thermophila CU428.2
Mol. Microbiol.
103
134-150
2017
1
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13
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749335
Rezabkova
Structural basis of katanin p ...
Mus musculus
Sci. Rep.
7
14893
2017
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1
1
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747634
Joly
Microtubule-severing activity ...
Caenorhabditis elegans
Development
143
3604-3614
2016
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2
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748655
Cheung
Proteomic analysis of the mam ...
Homo sapiens
Mol. Cell. Proteomics
15
1658-1669
2016
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1
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747284
Bailey
Katanin severing and binding ...
Homo sapiens, Xenopus laevis
Biophys. J.
109
2546-2561
2015
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749052
Grode
The non-catalytic domains of ...
Drosophila melanogaster
PLoS ONE
10
e0123912
2015
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1
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749069
Abu-Abied
Analysis of microtubule-assoc ...
Arabidopsis thaliana, Arabidopsis thaliana ecotype Columbia
PLoS ONE
10
e0143828
2015
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734660
McNally
Katanin maintains meiotic meta ...
Caenorhabditis elegans
Mol. Biol. Cell
25
1037-1049
2014
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1
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3
1
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3
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2
2
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735108
Matsuo
Katanin p60 contributes to mic ...
Rattus norvegicus
PLoS ONE
8
e80392
2013
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1
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4
1
1
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4
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1
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1
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3
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2
1
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3
3
-
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718995
Lumb
The AAA ATPase spastin links m ...
Homo sapiens
Biochim. Biophys. Acta
1823
192-197
2012
-
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1
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719465
Iwaya
Effect of Ca2+ on the microtub ...
Mus musculus
FEBS J.
279
1339-1352
2012
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1
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720033
Eckert
Subunit interactions and coope ...
Homo sapiens
J. Biol. Chem.
287
26278-26290
2012
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1
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1
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720339
Taylor
Crystal structure of the human ...
Homo sapiens
J. Struct. Biol.
179
133-137
2012
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1
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6
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720340
Onitake
The C-terminal alpha-helix of ...
Caenorhabditis elegans
J. Struct. Biol.
179
138-142
2012
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1
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713085
Zhang
Drosophila katanin is a microt ...
Drosophila melanogaster
Nat. Cell Biol.
13
361-369
2011
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720295
Draberova
Microtubule-severing ATPase sp ...
Homo sapiens
J. Neuropathol. Exp. Neurol.
70
811-826
2011
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1
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1
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712432
Iwaya
A common substrate recognition ...
Mus musculus
J. Biol. Chem.
285
16822-16829
2010
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1
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696656
Matsuno
Bis(hetero)aryl derivatives as ...
Homo sapiens
Bioorg. Med. Chem. Lett.
19
1058-1061
2009
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26
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26
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26
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701334
Connell
Spastin couples microtubule se ...
Homo sapiens
Traffic
10
42-56
2009
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712104
Matsushita-Ishiodori
Conserved aromatic and basic a ...
Caenorhabditis elegans
Genes Cells
14
925-940
2009
1
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1
1
4
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2
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1
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6
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Roll-Mecak
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Human spastin has multiple mic ...
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Regulation of microtubule seve ...
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The Caenorhabditis elegans mic ...
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Katanin inhibition prevents th ...
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1
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210539
Quarmby
Cellular Samurai: katanin and ...
Arabidopsis sp., Caenorhabditis elegans, Chlamydomonas reinhardtii, Drosophila sp. (in: Insecta), Homo sapiens, no activity in Saccharomyces cerevisiae, Xenopus laevis
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6
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3
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3
1
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1
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12
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3
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12
3
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210537
Lohret
Cloning of Chlamydomonas p60 k ...
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7
8
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4
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8
3
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2
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7
8
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2
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8
3
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2
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6
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6
2
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210534
Hartman
Katanin, a microtubule-severin ...
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6
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3
2
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1
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3
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2
14
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1
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6
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14
3
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1
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210535
Lohret
A role for katanin-mediated ax ...
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4
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2
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8
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210536
McNally
Katanin is responsible for the ...
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7
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2
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2
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14
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1
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9
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14
4
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Katanin, the microtubule-sever ...
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4
2
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210532
McNally
Identification of katanin, an ...
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4
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10
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4
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