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Literature summary for 5.6.1.1 extracted from

  • Lohret, T.A.; McNally, F.J.; Quarmby, L.M.
    A role for katanin-mediated axonemal severing during Chlamydomonas deflagellation (1998), Mol. Biol., 9, 1195-1207.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.1.1

Cloned(Commentary)

Cloned (Comment) Organism
human katanin cloned and expressed in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ADP
-
 Chlamydomonas reinhardtii
ADP
-
 Strongylocentrotus purpuratus
ATPgammaS
-
 Chlamydomonas reinhardtii
ATPgammaS
-
 Strongylocentrotus purpuratus

Localization

Localization Comment Organism GeneOntology No. Textmining
centrosome
-
 Homo sapiens 5813
-
centrosome
-
 Xenopus laevis 5813
-
centrosome
-
 Strongylocentrotus purpuratus 5813
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Chlamydomonas reinhardtii

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
 Western analysis using a polyclonal antibody against the 60 kDa subunit of human katanin Chlamydomonas reinhardtii
60000
-
-
 Homo sapiens
60000
-
-
 Strongylocentrotus purpuratus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Chlamydomonas reinhardtii
-
 ADP + phosphate
-
 ?
ATP + H2O Homo sapiens
-
 ADP + phosphate
-
 ?
ATP + H2O Xenopus laevis
-
 ADP + phosphate
-
 ?
ATP + H2O Strongylocentrotus purpuratus
-
 ADP + phosphate
-
 ?
GTP + H2O Chlamydomonas reinhardtii
-
 GDP + phosphate
-
 ?
GTP + H2O Homo sapiens
-
 GDP + phosphate
-
 ?
GTP + H2O Xenopus laevis
-
 GDP + phosphate
-
 ?
GTP + H2O Strongylocentrotus purpuratus
-
 GDP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Chlamydomonas reinhardtii
-
 strains 137c, cc620 and cc621
-
Homo sapiens
-
 human
-
Strongylocentrotus purpuratus
-
 sea urchin
-
Xenopus laevis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Chlamydomonas reinhardtii

Reaction

Reaction Comment Organism Reaction ID
n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome Chlamydomonas reinhardtii
a
n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome Homo sapiens
a
n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome Xenopus laevis
a
n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome Strongylocentrotus purpuratus
a

Source Tissue

Source Tissue Comment Organism Textmining
oocyte
-
 Xenopus laevis
-
oocyte
-
 Strongylocentrotus purpuratus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Chlamydomonas reinhardtii ADP + phosphate
-
 ?
ATP + H2O
-
 Homo sapiens ADP + phosphate
-
 ?
ATP + H2O
-
 Xenopus laevis ADP + phosphate
-
 ?
ATP + H2O
-
 Strongylocentrotus purpuratus ADP + phosphate
-
 ?
GTP + H2O
-
 Chlamydomonas reinhardtii GDP + phosphate
-
 ?
GTP + H2O
-
 Homo sapiens GDP + phosphate
-
 ?
GTP + H2O
-
 Xenopus laevis GDP + phosphate
-
 ?
GTP + H2O
-
 Strongylocentrotus purpuratus GDP + phosphate
-
 ?