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microglial cell
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colorectal tumors exhibit enhanced PI 3-kinase activity compared with normal colonic mucosa
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colorectal tumors exhibit enhanced PI 3-kinase activity compared with normal colonic mucosa
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the regulatory subunit p87PIKAP and the catalytic subunit p101 are both expressed
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umbilical vein endothelial cells
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primary tumor cell line
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nodal metastasis cell line
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sympathetic superior cervical ganglia and sensory trigeminal ganglia. In cultured sympathetic superior cervical ganglia and dorsal root ganglia neurons, p110a, b, and g immunoreactivity is in the sympathetic superior cervical ganglia and DRG growth cones, and predominantly in puncta throughout the growth cone varicosity
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primary glioblastoma
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HCT-116 cells are heterozygous for gain of function mutant PIK3CA H1047R
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chicken HD11 macrophage cell
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IL-3-dependent FDCP-1/Mac-1 murine hemopoietic progenitors
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a primary cell type in the liver responsible for excess collagen deposition during fibrosis
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Fao hepatoma cells
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HaCaT
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a N-terminal truncated form is found in lung
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the regulatory subunit p87PIKAP and the catalytic subunit p101 are both expressed
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primary
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insulinoma cell
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a promyelocytic leukemia cell line, expression of different PI3K isoforms during granulocyte differentiation of NB4 cells induced by all-trans-retinoic acid, 9-cis-retinoic acid or retinoic acid receptor agonists, overview
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shell and core. Cocaine sensitization decreases PI3K activity in nuclear accumbens core. The changes are not normalized following the reversal of cocaine-sensitization. Cocaine-sensitized animals exhibited increased PI3K activity in the nuclear accumbens shell, and this increase is reversed by combined pergolide/ondansetron treatment. Selective enhancement of the PI3K activity in the NAc shell may be one of key alterations underlying the long-term cocaine sensitization
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HSC-2
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inhibition of PI3-kinase induces apoptotic cell death, which is mediated by inactivation of Akt pathway in rat osteoblasts
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KF, KFTx, SHIN-3, KOC-2S, and SK-OV-3. Simultaneous inhibition of the mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase pathways enhances sensitivity to paclitaxel in ovarian carcinoma
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cocaine sensitization increases PI3K activity. The changes are not normalized following the reversal of cocaine-sensitization
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of rat embryonic cortex
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a cell line overexpressing the HER2/c-erb-2 gene product
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vascular
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anaplastic and follicular thyroid carcinoma
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ATCC CRTL-1486
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primary, obtained from subcutaneous tissue biopsies performed on two lean non-diabetic male subjects
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insulin-sensitive mouse 3T3-L1 adipocytes
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3T3-L1
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during differentiation of 3T3-L1 cells into adipocytes, isoform p110b is up-regulated approximately 10-fold, expression of p110a is unaltered
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expression and morphological analyses of PIK3C3 during mouse brain development, overview
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embryonic
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nuclear accumbens shell and core, prefrontal cortex
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ER-positive breast cancer cells (UMB-1Ca) are grown as tumors in ovariectomized athymic nude mice
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CHO cells
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carcinoma-derived A431 cells
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U937 monocyte
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U937 monocytes
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osteosarcoma sensitive and multidrug-resistant Saos-2 cells
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HL-60 cells
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breast cancer cells
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B lymphoma cell line
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osteosarcoma Saos-2 cells
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carcinoma-derived A431 cells
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BAF3 cells and primary murine megakaryocyte
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a N-terminal truncated form is found a certain hematopoietic cell line
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3T3-L1 cells
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T cell line CTLL-2
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Friend erythroleukemia cells
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Swiss 3T3 fibroblast
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of astrocytes from cerebral cortices
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of astrocytes from cerebral cortices
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PC12 cells
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KRC-7 hepatoma cells
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Fao hepatoma cells
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hepatocyte primary culture
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PC 12 cells
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fibroblasts
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isoform P110d
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airway, primary cells
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from embryo
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Swiss 3T3 fibroblast
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embryonic fibroblast cells
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thyroid follicular cell line
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ATCC CRL8305
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p87PIKAP is a regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with phosphodiesterase 3B
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activation of the prosurvival phosphatidylinositol 3-kinase-Akt pathway is involved in the protective action of poly(ADP-ribose) polymerase 1 inhibition in a model of donor heart procurement and hypothermic storage
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isoform P110d
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p110delta is exclusively found in leukocytes
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isozyme Ia gamma
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isozyme Ia gamma
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of obese diabetic mouse
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expression increases during liver regeneration after partial hepatectomy with maximal expression after the growth period, PI3K-IIgamma may function mainly in highly differentiated hepatic cells
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U937 monocyte
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airway smooth muscle cells
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of obese diabetic mouse
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skeletal muscle
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isozyme phosphatidylinositol 3-kinase gamma
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isozyme phosphatidylinositol 3-kinase gamma
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cultured sympathetic superior cervical ganglia and dorsal root ganglion neurons
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in immature hippocampal neurons, the enzyme is distributed in soma, Tau-1-positive axon, MAP2-positive dendrites, and nucleus. Moderate distribution of PIK3C3 at the perinuclear region
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pyramidal neurons, sensory neurons, and cortical neurons
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primary, cortical
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short-term spikes of modest heat abrogate antineutrophil cytoplasmic autoantibody-induced activation of neutrophils via inhibition of PI 3-kinase/Akt signaling
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the regulatory subunit p87PIKAP and the catalytic subunit p101 are both expressed
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the phosphatidylinositol 3-kinase-mediated production of interferon-beta is critical for the lipopolysaccharide inhibition of osteoclastogenesis
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PC3M
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PI3K regulates NADPH oxidase activity through modulating the recruitment of Rac-1 to plasma membrane and accelerates the process of rice seed germination
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insulin-stimulated insulin receptor substrate-2-associated phosphatidylinositol 3-kinase activity is enhanced in human skeletal muscle after exercise
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T cell line CTLL-2
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glioblastoma cell
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glioblastoma cell
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activation of PI3K signaling is required for the inhibitory effect of Axl on mineral deposition
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additional information
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isozymes Ia alpha and Ia beta are widely expressed in tissues
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additional information
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isozymes Ia alpha and beta are widely expressed in tissues
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additional information
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the phosphatidylinositol 3-kinase, PI3K, family is a family of conserved lipid and protein kinases that are ubiquitously expressed in many cells, including the heart
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additional information
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the phosphatidylinositol 3-kinase, PI3K, family is a family of conserved lipid and protein kinases that are ubiquitously expressed in many cells, including the heart
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additional information
the enzyme is secreted intracellularly in the host cell by Rickettsia typhi. Risk1 is present in both the pellet and supernatant of infected cells, implying that Risk1 is secreted into the host cell cytoplasm. Risk1 is deposited on the rickettsial cell surface after translocation through the secretion channel and is delivered into the host cell environment during Rickettsia typhi infection. Strong colocalization is observed between wild-type Risk1 and the tagged biosensors for PI(3)P, PI(3,4,5)P3, PI(3,4)P2, and PI(4,5)P2 in host cells
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additional information
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the enzyme is secreted intracellularly in the host cell by Rickettsia typhi. Risk1 is present in both the pellet and supernatant of infected cells, implying that Risk1 is secreted into the host cell cytoplasm. Risk1 is deposited on the rickettsial cell surface after translocation through the secretion channel and is delivered into the host cell environment during Rickettsia typhi infection. Strong colocalization is observed between wild-type Risk1 and the tagged biosensors for PI(3)P, PI(3,4,5)P3, PI(3,4)P2, and PI(4,5)P2 in host cells
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additional information
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the enzyme is secreted intracellularly in the host cell by Rickettsia typhi. Risk1 is present in both the pellet and supernatant of infected cells, implying that Risk1 is secreted into the host cell cytoplasm. Risk1 is deposited on the rickettsial cell surface after translocation through the secretion channel and is delivered into the host cell environment during Rickettsia typhi infection. Strong colocalization is observed between wild-type Risk1 and the tagged biosensors for PI(3)P, PI(3,4,5)P3, PI(3,4)P2, and PI(4,5)P2 in host cells
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additional information
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the enzyme is secreted intracellularly in the host cell by Rickettsia typhi. Risk1 is present in both the pellet and supernatant of infected cells, implying that Risk1 is secreted into the host cell cytoplasm. Risk1 is deposited on the rickettsial cell surface after translocation through the secretion channel and is delivered into the host cell environment during Rickettsia typhi infection. Strong colocalization is observed between wild-type Risk1 and the tagged biosensors for PI(3)P, PI(3,4,5)P3, PI(3,4)P2, and PI(4,5)P2 in host cells
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