Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.137 extracted from

  • Leblais, V.; Jo, S.H.; Chakir, K.; Maltsev, V.; Zheng, M.; Crow, M.T.; Wang, W.; Lakatta, E.G.; Xiao, R.P.
    Phosphatidylinositol 3-kinase offsets cAMP-mediated positive inotropic effect via inhibiting Ca2+ influx in cardiomyocytes (2004), Circ. Res., 95, 1183-1190.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
forskolin activates enzyme activity Rattus norvegicus
IGF-1 stimulates Rattus norvegicus
additional information stimulation of beta1-adrenergic receptor increases the enzyme activity in cardiomyocyte via the PKA-dependent mechanism involving Gbetagamma Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
LY294002 specific inhibition Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + phosphatidylinositol 4,5-bisphosphate Rattus norvegicus
-
ADP + phosphatidylinositol 3,4,5-trisphosphate
-
?
additional information Rattus norvegicus the enzyme is involved in beta2-adrenergic receptor/G1-mediated compartmentation of the concurrent Gs-cAMP signaling, negating beta2-AR-induced phospholamban phosphorylation and the positive inotropic and lusitropic responses in cardiomyocytes, regulation of enzyme activity in cell signaling cascades, effects of enzyme inhibition on cellular processes, detailed overview ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiac myocyte
-
Rattus norvegicus
-
heart
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + phosphatidylinositol 4,5-bisphosphate
-
Rattus norvegicus ADP + phosphatidylinositol 3,4,5-trisphosphate
-
?
additional information the enzyme is involved in beta2-adrenergic receptor/G1-mediated compartmentation of the concurrent Gs-cAMP signaling, negating beta2-AR-induced phospholamban phosphorylation and the positive inotropic and lusitropic responses in cardiomyocytes, regulation of enzyme activity in cell signaling cascades, effects of enzyme inhibition on cellular processes, detailed overview Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
phosphatidylinositol 3-kinase
-
Rattus norvegicus
PI3K
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information
-
Rattus norvegicus