Activating Compound | Comment | Organism | Structure |
---|---|---|---|
forskolin | activates enzyme activity | Rattus norvegicus | |
IGF-1 | stimulates | Rattus norvegicus | |
additional information | stimulation of beta1-adrenergic receptor increases the enzyme activity in cardiomyocyte via the PKA-dependent mechanism involving Gbetagamma | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
LY294002 | specific inhibition | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + phosphatidylinositol 4,5-bisphosphate | Rattus norvegicus | - |
ADP + phosphatidylinositol 3,4,5-trisphosphate | - |
? | |
additional information | Rattus norvegicus | the enzyme is involved in beta2-adrenergic receptor/G1-mediated compartmentation of the concurrent Gs-cAMP signaling, negating beta2-AR-induced phospholamban phosphorylation and the positive inotropic and lusitropic responses in cardiomyocytes, regulation of enzyme activity in cell signaling cascades, effects of enzyme inhibition on cellular processes, detailed overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiac myocyte | - |
Rattus norvegicus | - |
heart | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + phosphatidylinositol 4,5-bisphosphate | - |
Rattus norvegicus | ADP + phosphatidylinositol 3,4,5-trisphosphate | - |
? | |
additional information | the enzyme is involved in beta2-adrenergic receptor/G1-mediated compartmentation of the concurrent Gs-cAMP signaling, negating beta2-AR-induced phospholamban phosphorylation and the positive inotropic and lusitropic responses in cardiomyocytes, regulation of enzyme activity in cell signaling cascades, effects of enzyme inhibition on cellular processes, detailed overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol 3-kinase | - |
Rattus norvegicus |
PI3K | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Rattus norvegicus |