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Literature summary for 2.7.1.137 extracted from

  • Fukushima, T.; Nakamura, Y.; Yamanaka, D.; Shibano, T.; Chida, K.; Minami, S.; Asano, T.; Hakuno, F.; Takahashi, S.
    Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation (2012), J. Biol. Chem., 287, 29713-29721.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
FRTL-5 cell ATCC CRL8305 Rattus norvegicus
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General Information

General Information Comment Organism
physiological function insulin-like growth factor-I stimulation leads to prolonged association of phosphatidylinositol 3-kinase with insulin-like growth factor-I receptor. Phosphatidylinositol 3-kinase activity is present in this complex in thyrocytes and fibroblasts. Insulin-like growth factor-I withdrawal in mid-G1 phase impairs the association of phosphatidylinositol 3-kinase with insulin-like growth factor-I receptor and suppresses DNA synthesis the same as when phosphatidylinositol 3-kinase inhibitor is added. Residues Tyr1316-X-X-Met of insulin-like growth factor-I receptor function as a phosphatidylinositol 3-kinase binding sequence when this tyrosine is phosphorylated. In cells expressing exogenous mutant insulin-like growth factor-I receptor in which Tyr1316 is substituted with Phe, insulin-like growth factor-I stimulation induces tyrosine phosphorylation of insulin-like growth factor-I receptor and insulin receptor substrates-1/2, but mutated insulin-like growth factor-IR fails to bind phosphatidylinositol 3-kinase and to induce maximal phosphorylation of GSK3 and cell proliferation in response to insulin-like growth factor-I. Phosphatidylinositol 3-kinase activity bound to insulin-like growth factor-I receptor, which is continuously sustained by insulin-like growth factor-I stimulation, is required for insulin-like growth factor-I-induced cell proliferation Rattus norvegicus