Literature summary for 2.7.1.137 extracted from

Kinoshita, H.; Matsuda, N.; Kaba, H.; Hatakeyama, N.; Azma, T.; Nakahata, K.; Kuroda, Y.; Tange, K.; Iranami, H.; Hatano, Y.
Roles of phosphatidylinositol 3-kinase-Akt and NADPH oxidase in adenosine 5-triphosphate-sensitive K+ channel function impaired by high glucose in the human artery (2008), Hypertension, 52, 507-513.

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Inhibitors

Inhibitors	Comment	Organism	Structure
apocynin	specific PI3K inhibitor, restores vasorelaxation and hyperpolarization in response to an ATP-sensitive K+ channel opener levcromakalim	Homo sapiens
LY294002	specific PI3K inhibitor, restores vasorelaxation and hyperpolarization in response to an ATP-sensitive K+ channel opener levcromakalim	Homo sapiens
Tiron	specific PI3K inhibitor, restores vasorelaxation and hyperpolarization in response to an ATP-sensitive K+ channel opener levcromakalim	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Homo sapiens	16020	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
artery	-	Homo sapiens	-
vascular smooth muscle cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PI3K	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	the enzyme is part of the phosphatidylinositol 3-kinase-Akt pathway, which plays a role in the adenosine 5'-triphosphate-sensitive K+ channel function, overview	Homo sapiens

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Release 2023.1 (January 2023)