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Literature summary for 2.7.1.137 extracted from

  • Hai, J.; Lin, Q.; Lu, Y.
    Phosphatidylinositol 3-kinase activity is required for the induction of differentiation in C6 glioma cells by panaxydol (2009), J. Clin. Neurosci., 16, 444-448.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Wortmannin a specific PI 3-K inhibitor Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
C6 glioma cell
-
Rattus norvegicus
-
glioma cell
-
Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
PI 3-K
-
Rattus norvegicus

General Information

General Information Comment Organism
physiological function differentiation in C6 cells by panaxydol, isolated from the lipophilic fractions of Tienchi ginseng, Panax notoginseng, might be mediated through a PI 3-K-dependent pathway. Treatment of C6 cells with panaxydol causes marked inhibition of growth that is abolished by wortmannin, a PI 3-K inhibitor Rattus norvegicus