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2.7.1.137: phosphatidylinositol 3-kinase

This is an abbreviated version!
For detailed information about phosphatidylinositol 3-kinase, go to the full flat file.

Word Map on EC 2.7.1.137

Reaction

ATP
+
1-phosphatidyl-1D-myo-inositol
=
ADP
+
1-phosphatidyl-1D-myo-inositol 3-phosphate

Synonyms

class 3 phosphatidylinositol 3-kinase vacuolar protein sorting 34, class I phosphoinositide 3-kinase, class III phosphatidylinositol 3-kinase, class III phosphoinositide 3-kinase, class III PI3K, HsC2-PI3K, hVps34, hVps34 PI 3-kinase, kinase (phosphorylating), phosphatidylinositol 3-, kinase, phosphatidylinositol 3- (phosphorylating), lipid kinase Vps34, mammalian vacuolar protein sorting 34 homologue, More, p110a, p110delta I PI3K., p110g-related PI 3-kinase, p85/p110 phosphoinositide 3-kinase, p85/p110 type phosphatidylinositol kinase, p85a phosphoinositide 3-kinase, phosphatidyl-inositol-3-kinase, phosphatidylinositide 3-kinase, phosphatidylinositide 3-kinase C2alpha, phosphatidylinositol 3 kinase, phosphatidylinositol 3'-kinase, phosphatidylinositol 3-kinase, phosphoinositide 3'-kinase, phosphoinositide 3-kinase, phosphoinositide 3-kinase Dp110, phosphoinositide 3-kinase gamma, phosphoinositide-3-kinase, PI 3-K, PI 3-kinase, PI-3-K, PI-3K, PI3 K, PI3 kinase, PI3-K, PI3-K-related protein MEC1, PI3-kinase, PI3K, PI3K type III, PI3Kalpha, PI3Kbeta, PI3Kgamma, PI3K_59F, PI3K_68D, PIK3, PIK3C3, protein sorting mutant 34 protein, PtdIns 3'-kinase, PtdIns 3-kinase, PtdIns 3-kinase vacuolar protein sorting 34, receptor-linked phosphatidylinositol 3-kinase, Rickettsia intracellular secreted kinase-1, Risk1, RT0135, TcVps34, type III phosphatidylinositol 3-kinase, vacuolar protein sorting 34, VPS34, Vps34p

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.137 phosphatidylinositol 3-kinase

IC50 Value

IC50 Value on EC 2.7.1.137 - phosphatidylinositol 3-kinase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000002
(8S)-2-[(3R)-3-methylmorpholin-4-yl]-9-(3-methyl-2-oxobutyl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one
Homo sapiens
pH and temperature not specified in the publication
0.2
2-morpholin-4-yl-3-phenylchromen-4-one
Homo sapiens
-
weak inhibition, IC50 is above 0.2 mM for the recombinant wild-type enzyme and for the recombinant mutant C838V/I848A
0.0031
2-morpholin-4-yl-3-propylchromen-4-one
Homo sapiens
-
IC50 is 0.0031 mM for the recombinant wild-type enzyme and 0.068 mM for the recombinant mutant C838V/I848A
0.2
3-benzyl-2-morpholin-4-yl-chromen-4-one
Homo sapiens
-
weak inhibition, IC50 is above 0.2 mM for the recombinant wild-type enzyme and for the recombinant mutant C838V/I848A
0.025
3-butyl-2-morpholin-4-yl-chromen-4-one
Homo sapiens
-
IC50 is 0.025 mM for the recombinant wild-type enzyme and 0.048 mM for the recombinant mutant C838V/I848A
0.028
3-ethyl-2-morpholin-4-yl-chromen-4-one
Homo sapiens
-
IC50 is 0.028 mM for the recombinant wild-type enzyme and 0.0044 mM for the recombinant mutant C838V/I848A
0.051
3-isopropyl-2-morpholin-4-yl-chromen-4-one
Homo sapiens
-
IC50 is 0.051 mM for the recombinant wild-type enzyme and more than 0.2 mM for the recombinant mutant C838V/I848A
0.033
3-methyl-2-morpholin-4-yl-chromen-4-one
Homo sapiens
-
IC50 is 0.033 mM for the recombinant wild-type enzyme and 0.040 mM for the recombinant mutant C838V/I848A
0.000036
3-Methyladenine
Homo sapiens
pH and temperature not specified in the publication
0.01
GDC-0941
Homo sapiens
above, pH and temperature not specified in the publication
0.0026
LY292223
Homo sapiens
-
i.e. 2-morpholin-4-yl-chromen-4-one, IC50 is 0.0026 mM for the recombinant wild-type enzyme and 0.025 mM for the recombinant mutant C838V/I848A
0.0011 - 2
LY294002
0.065
LY303511
Rattus norvegicus
-
the inhibitor potently, reversibly blocks voltage-dependent K+ channel currents via a direct mechanism, IC50 is 0.065 mM
0.000488
PI-103
Homo sapiens
pH and temperature not specified in the publication
0.000018
PIK-III
Homo sapiens
pH and temperature not specified in the publication
-
0.0000012
SAR405
Homo sapiens
pH and temperature not specified in the publication
0.000025
Vps34-IN-1
Homo sapiens
pH and temperature not specified in the publication
-
0.00001 - 0.000012
Wortmannin