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Literature summary for 2.7.1.137 extracted from

  • Montenegro, D.E.; Franklin, T.; Moscinski, L.C.; Zuckerman, K.S.; Hu, X.T.
    TGFbeta inhibits GM-CSF-induced phosphorylation of ERK and MEK in human myeloid leukaemia cell lines via inhibition of phosphatidylinositol 3-kinase (PI3-k) (2009), Cell Prolif., 42, 1-9.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
LY294002 a potent inhibitor of PI3-kinase, significantly inhibits phosphorylation of both p85 and ERK1/2 in vivo Homo sapiens
TGFbeta significantly inhibits phosphorylation of both p85 and ERK1/2 in vivo. TGFbeta does not activate the ERK pathway but turns off the GM-CSF-induced ERK signal via inhibition of the PI3-kinase-Akt pathway in human leukemia cells, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leukemia cell
-
 Homo sapiens
-
MV4-11 cell
-
 Homo sapiens
-
TF-1 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
PI3-K
-
 Homo sapiens