Literature summary for 2.7.1.137 extracted from

Ashizawa, K.; Omura, Y.; Katayama, S.; Tatemoto, H.; Narumi, K.; Tsuzuki, Y.
Intracellular signal transduction pathways in the regulation of fowl sperm motility: evidence for the involvement of phosphatidylinositol 3-kinase (PI3-K) cascade (2009), Mol. Reprod. Dev., 76, 603-610.

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Inhibitors

Inhibitors	Comment	Organism	Structure
LY294002	i.e. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, a specific cell-permeable PI3-K inhibitor, inhibits spermatozoa motility at 40°C, not at 30°C, independent of and not reversable by Ca2+	Gallus gallus
additional information	LY303511, i.e. 2-(4-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one, is an inactive analogue of LY294002	Gallus gallus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
85000	-	1 * 85000, regulatory subunit, + 1 * 110000, catalytic subunit, SDS-PAGE	Gallus gallus
110000	-	1 * 85000, regulatory subunit, + 1 * 110000, catalytic subunit, SDS-PAGE	Gallus gallus

Organism

Organism	UniProt	Comment	Textmining
Gallus gallus	-	fowl	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
spermatozoon	-	Gallus gallus	-

Subunits

Subunits	Comment	Organism
dimer	1 * 85000, regulatory subunit, + 1 * 110000, catalytic subunit, SDS-PAGE	Gallus gallus

Synonyms

Synonyms	Comment	Organism
PI3-K	-	Gallus gallus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
30	40	assay at	Gallus gallus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Gallus gallus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Gallus gallus

General Information

General Information	Comment	Organism
physiological function	PI3-K is involved in the intracellular signal transduction pathways in the regulation of fowl sperm motility, the calcium-regulated maintenance of flagellar movement, and in reversible temperature-dependent immobilization at 40°C, but PI3K is probably not involved in regulation of Ca2+ mobilization	Gallus gallus

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Release 2023.1 (January 2023)