Literature summary for 2.7.1.137 extracted from

Curnock, A.P.; Ward, S.G.
Development and characterization of tetracycline-regulated phosphoinositide 3-kinase mutants: assessing the role of multiple phosphoinositide 3-kinases in chemokine signaling (2003), J. Immunol. Methods, 273, 29-41.

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Cloned(Commentary)

Cloned (Comment)	Organism
construction of a tetracycline-inducible expression system by introducing a regulatory plasmid, which constitutively expresses tetracycline-sensitive transactivator, and a response plasmid, containing a tetracycline response element in form of a heptameric repeat of the tetR binding site, under control of a minimal CMV promotor, into Jurkat cells, individual and coexpression of the Myc-tagged enzyme subunits in the Jurkat cell system, determination of expression levels, overview	Homo sapiens

Cloned (Comment)

Organism

construction of a tetracycline-inducible expression system by introducing a regulatory plasmid, which constitutively expresses tetracycline-sensitive transactivator, and a response plasmid, containing a tetracycline response element in form of a heptameric repeat of the tetR binding site, under control of a minimal CMV promotor, into Jurkat cells, individual and coexpression of the Myc-tagged enzyme subunits in the Jurkat cell system, determination of expression levels, overview

Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
85000	-	1 * 85000, class IA regulatory/adaptor subunit, + 1 * 110000, class IB catalytic subunit	Homo sapiens
110000	-	1 * 85000, class IA regulatory/adaptor subunit, + 1 * 110000, class IB catalytic subunit	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	the enzyme is involved in cytokin-stimulated cell migration	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
JURKAT cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme is involved in cytokin-stimulated cell migration	Homo sapiens	?	-	?

Subunits

Subunits	Comment	Organism
dimer	1 * 85000, class IA regulatory/adaptor subunit, + 1 * 110000, class IB catalytic subunit	Homo sapiens

Synonyms

Synonyms	Comment	Organism
phosphoinositide 3-kinase	-	Homo sapiens