Activating Compound | Comment | Organism | Structure |
---|---|---|---|
adenosine | adenosine activates PI3K and induces Akt phosphorylation leading to induction of hemeoxygenase-1, HO-1, expression in microglia. Adenosine acts as an endogenous regulator of brain inflammation via modulation of microglial reactive oxygen species production, mechanism, overview | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
LY294002 | - |
Rattus norvegicus | |
Wortmannin | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | activation of PI3K by adenosine leads to induction of hemeoxygenase-1, HO-1, expression in microglia | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Sprague Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
microglia | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | activation of PI3K by adenosine leads to induction of hemeoxygenase-1, HO-1, expression in microglia | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PI3K | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |