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2.7.1.137: phosphatidylinositol 3-kinase

This is an abbreviated version!
For detailed information about phosphatidylinositol 3-kinase, go to the full flat file.

Word Map on EC 2.7.1.137

Reaction

ATP
+
1-phosphatidyl-1D-myo-inositol
=
ADP
+
1-phosphatidyl-1D-myo-inositol 3-phosphate

Synonyms

class 3 phosphatidylinositol 3-kinase vacuolar protein sorting 34, class I phosphoinositide 3-kinase, class III phosphatidylinositol 3-kinase, class III phosphoinositide 3-kinase, class III PI3K, HsC2-PI3K, hVps34, hVps34 PI 3-kinase, kinase (phosphorylating), phosphatidylinositol 3-, kinase, phosphatidylinositol 3- (phosphorylating), lipid kinase Vps34, mammalian vacuolar protein sorting 34 homologue, More, p110a, p110delta I PI3K., p110g-related PI 3-kinase, p85/p110 phosphoinositide 3-kinase, p85/p110 type phosphatidylinositol kinase, p85a phosphoinositide 3-kinase, phosphatidyl-inositol-3-kinase, phosphatidylinositide 3-kinase, phosphatidylinositide 3-kinase C2alpha, phosphatidylinositol 3 kinase, phosphatidylinositol 3'-kinase, phosphatidylinositol 3-kinase, phosphoinositide 3'-kinase, phosphoinositide 3-kinase, phosphoinositide 3-kinase Dp110, phosphoinositide 3-kinase gamma, phosphoinositide-3-kinase, PI 3-K, PI 3-kinase, PI-3-K, PI-3K, PI3 K, PI3 kinase, PI3-K, PI3-K-related protein MEC1, PI3-kinase, PI3K, PI3K type III, PI3Kalpha, PI3Kbeta, PI3Kgamma, PI3K_59F, PI3K_68D, PIK3, PIK3C3, protein sorting mutant 34 protein, PtdIns 3'-kinase, PtdIns 3-kinase, PtdIns 3-kinase vacuolar protein sorting 34, receptor-linked phosphatidylinositol 3-kinase, Rickettsia intracellular secreted kinase-1, Risk1, RT0135, TcVps34, type III phosphatidylinositol 3-kinase, vacuolar protein sorting 34, VPS34, Vps34p

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.137 phosphatidylinositol 3-kinase

Crystallization

Crystallization on EC 2.7.1.137 - phosphatidylinositol 3-kinase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystal structure of PI3K SH3 domain at 2.0 A resolution
-
in complex with inhibitor E5E2, hanging drop vapour diffusion method, 100 mM Tris pH 7.2, 200 mM ammonium sulfate, 21% PEG 4000
-
purified detagged recombinant PI3K SH3 domain, residues 1-83, crystallized in presence of peptide ligands PD1R or PD1, the crystals do not contain the PD1 ligand, instead, the ligand binding site is partially occupied by residues Arg18 and Trp55 from the symmetry-related PI3K SH3 molecule. Sitting drop vapor diffusion method by mixing of 0.001 ml of protein-peptide mixture and 0.001 ml of reservoir solution containing for PD1R crystals 100 mM CAPS buffer, pH 10.5, 2 M ammonium sulfate and 0.2 M lithium sulfate or for PD1 crystals 100 mM Na-citrate buffer, pH 5.5, 0.5 M ammonium sulfate and 1 M lithium sulfate, 17°C, several weeks, X-ray diffraction structure determination and analysis at 1.7 A resolution
-
vapor diffusion hanging drop method. Crystal structure of the C2 domain
-