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Literature summary for 2.7.1.137 extracted from

  • Shibasaki, F.; Fukui, Y.; Takenawa, T.
    Different properties of monomer and heterodimer forms of phosphatidylinositol 3-kinases (1993), Biochem. J., 289, 227-231.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
phosphatidic acid enhances activity more markedly for PI 3-kinase II than for PI 3-kinase I Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
adenosine above 0.1 mM Bos taurus
ADP above 0.1 mM Bos taurus
AMP above 0.1 mM Bos taurus
cardiolipin
-
Bos taurus
isoquercetin PI 3-kinase I and PI 3-kinase II; strong inhibition of PI 3-kinase I and II, noncompetitive, apparent Ki value: 4 mM for PI 3-kinase I and 2.5 mM for PI 3-kinase II Bos taurus
phosphatidylcholine strong inhibition of enzyme form PI3KII, weak inhibition of enzyme form PI3KI Bos taurus
quercetin inhibition of PI 3-kinase I and II; PI 3-kinase I and PI 3-kinase II, non-competitive Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bos taurus enzyme plays an important role in the signalling of cell growth ?
-
?
additional information Bos taurus enzyme plays an important role in the signaling of cell growth ?
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein putative PI 3-kinase 85000 Da subunit is phosphorylated by pp60vscr Bos taurus

Purification (Commentary)

Purification (Comment) Organism
PI3KI, monomeric form Bos taurus
PI3KII, heterodimeric form Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
thymus
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidylinositol
-
Bos taurus ADP + phosphatidylinositol 3-phosphate
-
?
additional information enzyme plays an important role in the signalling of cell growth Bos taurus ?
-
?
additional information enzyme plays an important role in the signaling of cell growth Bos taurus ?
-
?

Subunits

Subunits Comment Organism
More two types of PI 3-kinase a monomer form, PI 3-kinase I, and a heterodimeric form, PI 3-kinase II Bos taurus