Activating Compound | Comment | Organism | Structure |
---|---|---|---|
phosphatidic acid | enhances activity more markedly for PI 3-kinase II than for PI 3-kinase I | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
adenosine | above 0.1 mM | Bos taurus | |
ADP | above 0.1 mM | Bos taurus | |
AMP | above 0.1 mM | Bos taurus | |
cardiolipin | - |
Bos taurus | |
isoquercetin | PI 3-kinase I and PI 3-kinase II; strong inhibition of PI 3-kinase I and II, noncompetitive, apparent Ki value: 4 mM for PI 3-kinase I and 2.5 mM for PI 3-kinase II | Bos taurus | |
phosphatidylcholine | strong inhibition of enzyme form PI3KII, weak inhibition of enzyme form PI3KI | Bos taurus | |
quercetin | inhibition of PI 3-kinase I and II; PI 3-kinase I and PI 3-kinase II, non-competitive | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Bos taurus | enzyme plays an important role in the signalling of cell growth | ? | - |
? | |
additional information | Bos taurus | enzyme plays an important role in the signaling of cell growth | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | putative PI 3-kinase 85000 Da subunit is phosphorylated by pp60vscr | Bos taurus |
Purification (Comment) | Organism |
---|---|
PI3KI, monomeric form | Bos taurus |
PI3KII, heterodimeric form | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
thymus | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidylinositol | - |
Bos taurus | ADP + phosphatidylinositol 3-phosphate | - |
? | |
additional information | enzyme plays an important role in the signalling of cell growth | Bos taurus | ? | - |
? | |
additional information | enzyme plays an important role in the signaling of cell growth | Bos taurus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | two types of PI 3-kinase a monomer form, PI 3-kinase I, and a heterodimeric form, PI 3-kinase II | Bos taurus |