Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | 0.1 mM, 60% inhibition, in presence of 10 mM MgCl2 | Bos taurus | |
Dodecyl sucrose | - |
Bos taurus | |
Nonidet P40 | - |
Bos taurus | |
octylglucoside | - |
Bos taurus | |
sodium cholate | - |
Bos taurus | |
sodium deoxycholate | - |
Bos taurus | |
Triton X-100 | - |
Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Bos taurus | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | CaCl2 stimulates enzyme forms PI3KI and PI3KII in absence of MnCl2. Half-maximal activation of PI3KI at 0.1 mM Ca2+, maximal activity at 1 mM, in presence of 10 mM MgCl2 further 2fold activation by 2 mM Ca2+. For PI3KII maximal activity is obtained in presence of 2 mM Ca2+, 1.6fold higher than that obtained in presence of 10 mM MgCl2 | Bos taurus | |
Mg2+ | maximal activation at 5 mM | Bos taurus | |
Mg2+ | activation | Bos taurus | |
Mn2+ | scarcely activates | Bos taurus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
85000 | - |
1 * 110000 + 1 * 85000, enzyme form PI3KII, SDS-PAGE | Bos taurus |
110000 | - |
monomeric form PI3KI, gel filtration | Bos taurus |
190000 | - |
heterodimeric form PI3KII, gel filtration | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
PI3KI, monomeric form | Bos taurus |
PI3KII, heterodimeric form | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
thymus | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.05 | - |
dimeric enzyme form PI3KII | Bos taurus |
0.25 | - |
monomeric enzyme form PI3KI | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidylinositol | - |
Bos taurus | ADP + phosphatidylinositol 3-phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 1 * 110000 + 1 * 85000, enzyme form PI3KII, SDS-PAGE | Bos taurus |
monomer | 1 * 110000, enzyme form PI3KI, SDS-PAGE | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
enzyme forms PI3KII and PI3KI | Bos taurus |