Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of PI3Kgamma knockout PI3K-/- mice displaying highly reduced activity, poorer functional recovery, and greater tissue injury following ischemic preconditioning compared to wild-type and PI3Kgamma-/+ mutant hearts. Mice expressing a cardiac-specific kinase-deleted PI3Kalpha are resistant to injury induced by 30 min of ischemia followed by 40 min of reperfusion, their to ischemia/reperfusion correlates with the persistent expression of p110gamma and is blocked by the PI3K inhibitor wortmannin, phosphorylation patterns in PI3K signaling in mutant mice, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
LY294002 | - |
Mus musculus | |
Wortmannin | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol | Mus musculus | - |
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? | |
ATP + 1-phosphatidyl-1D-myo-inositol | Mus musculus C57BL/6 | - |
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? | |
additional information | Mus musculus | PI3K signaling, overview | ? | - |
? | |
additional information | Mus musculus C57BL/6 | PI3K signaling, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6 mice | - |
Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Mus musculus | - |
additional information | the phosphatidylinositol 3-kinase, PI3K, family is a family of conserved lipid and protein kinases that are ubiquitously expressed in many cells, including the heart | Mus musculus | - |
myocardium | isozyme phosphatidylinositol 3-kinase gamma | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol | - |
Mus musculus | ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? | |
ATP + 1-phosphatidyl-1D-myo-inositol | - |
Mus musculus C57BL/6 | ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? | |
additional information | PI3K signaling, overview | Mus musculus | ? | - |
? | |
additional information | PI3K signaling, overview | Mus musculus C57BL/6 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | the phosphatidylinositol 3-kinase, PI3K, family is a family of conserved lipid and protein kinases that are ubiquitously expressed in many cells, including the heart | Mus musculus |
PI3K | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | PI3K isozymes play selective roles in ischemic preconditioning, a potent cellular protective mechanism whereby brief periods of sublethal ischemia protect the myocardium from prolonged ischemia-induced injury, overview | Mus musculus |