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Literature summary for 2.7.1.137 extracted from

  • Ban, K.; Cooper, A.J.; Samuel, S.; Bhatti, A.; Patel, M.; Izumo, S.; Penninger, J.M.; Backx, P.H.; Oudit, G.Y.; Tsushima, R.G.
    Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning (2008), Circ. Res., 103, 643-653.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information generation of PI3Kgamma knockout PI3K-/- mice displaying highly reduced activity, poorer functional recovery, and greater tissue injury following ischemic preconditioning compared to wild-type and PI3Kgamma-/+ mutant hearts. Mice expressing a cardiac-specific kinase-deleted PI3Kalpha are resistant to injury induced by 30 min of ischemia followed by 40 min of reperfusion, their to ischemia/reperfusion correlates with the persistent expression of p110gamma and is blocked by the PI3K inhibitor wortmannin, phosphorylation patterns in PI3K signaling in mutant mice, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
LY294002
-
Mus musculus
Wortmannin
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol Mus musculus
-
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
?
ATP + 1-phosphatidyl-1D-myo-inositol Mus musculus C57BL/6
-
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
?
additional information Mus musculus PI3K signaling, overview ?
-
?
additional information Mus musculus C57BL/6 PI3K signaling, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
C57BL/6 mice
-
Mus musculus C57BL/6
-
C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Mus musculus
-
additional information the phosphatidylinositol 3-kinase, PI3K, family is a family of conserved lipid and protein kinases that are ubiquitously expressed in many cells, including the heart Mus musculus
-
myocardium isozyme phosphatidylinositol 3-kinase gamma Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol
-
Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
?
ATP + 1-phosphatidyl-1D-myo-inositol
-
Mus musculus C57BL/6 ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
?
additional information PI3K signaling, overview Mus musculus ?
-
?
additional information PI3K signaling, overview Mus musculus C57BL/6 ?
-
?

Synonyms

Synonyms Comment Organism
More the phosphatidylinositol 3-kinase, PI3K, family is a family of conserved lipid and protein kinases that are ubiquitously expressed in many cells, including the heart Mus musculus
PI3K
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus

General Information

General Information Comment Organism
physiological function PI3K isozymes play selective roles in ischemic preconditioning, a potent cellular protective mechanism whereby brief periods of sublethal ischemia protect the myocardium from prolonged ischemia-induced injury, overview Mus musculus